Interpretation of Leukocyte Responses in Disease Flashcards
Erythremic Myelosis
Red cell leukemia
Penia
decreased concentration of cells
Microscopic changes seen with neutrophil degeneration
Marked cytoplasmic vacuolation
Nuclear swelling
Cell lysis
Excitement Leukocyte Response
“Fight or Flight” response - increased blood flow through microcirculation results in shift of leukocytes from marginated pool to the circulating pool
Causes of monocytosis
Inflammation
Stress Response
Microscopic changes seen with Neutrophil Toxic Change
Increased basophilia of cytoplasm
Presence of Dohle bodies
Cytoplasmic Vacuolation
Cytopenia
Decreased concentration of neutrophils, lymphocytes and eosinophils
Causes of lymphopenia
Steroid response
Acute viral infection
Immunodeficiency
Inherited lymphocyte abnormalities
MPS and GM2 gangliosidosis - cytoplamsic granulation or vaculation
Alpha Mannosidosis - cytoplasmic vacuolation
Niemann Pick Disease - cytoplasma vacuolation
Acid Lipase Deficiency - cytoplasmic vacuolation
Fucosidosis - cytoplasmic vacuolation
Birman Cat neutrophil Granulation Anomaly
Of unknown cause
50% of Birman Cats have the disease
Can be confused with lysosomal storage disease
Excitement leukocyte response can result in
2x fold leukocyte concentration
Neutrophil Toxic Change
Due to accelerated rate of production seen with inflammation, which results in the persistance of ribosomes
Causes of Neutropenia
Consuption within inflammatory lesion
Immune mediated destruction
Lack of production by bone marrow
Neutrophil Degeneration
Describes neutrophils that are not in circulation
Lyphopenia, Neutrophilia and Eosinophilia can be seen with which leukocyte response?
Stress
Acquired changes in neutrophil morphology
Neutrophil Toxic Change
Neutrophil Hypersegmentation
Neutrophil Degeneration
Chediak-Higashi Syndrome
Due to fused lysosomes
Pink granules
Neutrophils do not kill or phagocytize as well as normal