Integration of Concepts: Keloid Flashcards
1
Q
Keloid
A
malfunction of the repair process; abnormal response to wound repair; overabundant collagen formation
2
Q
type 3 collagen
A
laid down by fibroblasts
3
Q
NO mechanism in keloid formation
A
NO signals fibroblasts and changes its proteome (upregulation of keloid factor proteins and TGF-b) which leads to the increase of ECM
4
Q
MMP
A
matrix metalloproteinase; responsible for the degradation of most extracellular matrix proteins during organogenesis, growth and normal tissue turnover.
5
Q
MMP regulation
A
- proteolytic activation
- proteolytic processing and inactivation
- protein inhibition (TIMPs)
- ECM localization
- cell surface localization
- endocytosis and intracellular degradation
6
Q
zymograms
A
can use to find inactive vs active MMPs; because active MMPs are cleaved, they will move farther down in the zymogram
7
Q
what inhibits MMP
A
TIMP- tissue inhibitor of metalloproteinase
