Insomnia Flashcards

1
Q

Facts about sleep

A

Sleep is vital

Part of circadian rhythm – many functions including growth, rest & recovery.

Pattern varies throughout life

Adults need 4 to 9 hours sleep

Deprivation leads to –ve effect on mood, motivation, alertness, memory & physical function.

Lab rats die after 14 days of no sleep!!

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2
Q

Normal adult sleep pattern in one night

A
Level of sleep is not the same
Goes via several stages of sleep 
REM- Shallowest stage of sleep, they are most aware and the brain is functional 
 waking in between cycle
They do not spend more time at REM sleep
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3
Q

Define Insomnia

A

A condition of unsatisfactory quantity and/or quality of
sleep which persists for a considerable period of time,
including difficulty falling asleep, difficulty in staying
asleep, or early final wakening.

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4
Q

Insomnia is a common

symptom of many mental and physical conditions. True or false?

A

True

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5
Q

How Insomnia is described

A
Can be indicated if an individual reports two or more of the following:
Take more than 30 mins to go to sleep
Difficulty maintaining sleep
Disturbed sleep  - >3 x per week
Daytime functioning impaired
Short but healthy sleep vs. insomnia
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6
Q

State the two types of Insomnia

A
  1. Primary Insomnia

2. Secondary Insomnia

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7
Q

What type of insomnia comes from an unknown origin or arises from sleep environment?

A

Primary Insomnia

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8
Q

Define secondary Insomnia

A

Insomnia that arises due to an underlying psychological or physical condition

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9
Q

List and briefly explain the classification of insomnia due to duration of symptoms

A
  1. Transient Insomnia- Lasts 2-3 days
  2. Short-term- Lasts longer than three days, but
    <3 weeks
  3. Long-term (chronic) -Lasts longer than three
    weeks
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10
Q

A high level of cortisol production during the day and at night time could result in lack of sleep. True/false.

A

True

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11
Q

What is the common reason for the excessive production of cortisol

A

One common reason for the excessive production of cortisol is tumor in the pituitary gland

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12
Q

Production of high levels of steroids hormones leads to what type of insomnia?

A

Secondary Insomnia

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13
Q

Most of the P medicines are licensed for short term and transient insomnia. True/false

A

True

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14
Q

Epidemiology of Insomnia

A

About 10-38% of all people have sleep problems in any given year
In a UK study, 30-48% of people reported insomnia symptoms and 8-18% sleep dissatisfaction, only 6% met the criteria for a diagnosis of insomnia
Prevalence seems to be greater in women, older people, and those who are socioeconomically disadvantaged
Insomnia typically develops at times of increased life stress

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15
Q

Primary Insomnia mainly caused by;

A
  1. A poor sleep environment e.g. light, noise, heat
  2. Behaviour that makes sleep difficult e.g.
    Physical / intellectual arousal
  3. Varying sleep routine – mismatch between
    attempts to sleep and circadian rhythm e.g. Jet-
    lag and shift
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16
Q

State the ‘5 P’s’ approach to causes of secondary Insomnia

A

1.Physical- CV disease; COPD/asthma; pain
2.Physiological- Late heavy meals, high in fat or
protein or both
3.Psychological- Stress; tension; grief;
ASPS/DSPS
4. Psychiatric- Mood and/or anxiety disorders
5. Pharmacological- Alcohol; medicines; illicit
recreational drugs

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17
Q

What is ASPS?

A

Advanced Sleep Phase Syndrome- The patient becomes really tired much earlier in the day than you would expect, they feel like its late at sort of tea time. Their 24 hour is shorter in ASPS

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18
Q

Whats DSPS?

A

Delayed Sleep Phase Syndrome- 24hour longer in
DSPS
This is where the patient does not keep to 24-hour pace circadian rhythm

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19
Q

Effect of Alcohol on the sleep cycle

A

Alcohol prevents deep sleep (REM) REM cycle from happening, it does not provide a refreshing sleep although it helps people to sleepalcohol-fuelled sleep is marked less refreshing than the non-alcohol fuelled sleep

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20
Q

List POMs which can cause insomnia

A
Anticonvulsants (Phenytoin, Lamotrigine)
Beta-blockers (Atenolol, Propranolol)
SSRIs (Fluoxetine, Sertraline)
Antiparkinson drugs (Levodopa)
Decongestants (Pseudoephedrine)
Corticosteroids (Prednisolone, Dexamethasone)
Levothyroxine
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21
Q

List Information needed for diagnosis of Insomnia

A

Detailed questioning required
Sleep diary
Patient records sleep diary over 2 weeks
Includes:
quantity of sleep, awakenings during night,
quality of sleep,
activity during the day, caffeine, nicotine

this helps to establish a pattern

22
Q

List the relevant information needed for the diagnosis of Insomnia

A

pattern of sleep
daily routine
underlying medical condition
Recent travel

23
Q

When to refer a patient suffering from Insomnia

A
Children under 12
Longer than 3 weeks
No known cause
Previous undiagnosed medical conditions
Symptoms of anxiety/depression
Other sleep disorders
Sleep apnoea
Narcolepsy
Hypersomnia
24
Q

List the available treatment options for Insomnia

A
Sleep hygiene
OTC Medication:
Diphenhydramine
Promethazine
Herbal products
POM Medication
25
Q

Sleep hygiene measures includes;

A

Sleep hygiene – developing a routine

Reducing caffeine, nicotine; address alcohol intake

Increasing exercise

Bathing before bedtime

Avoiding Carbohydrate intake before bed

26
Q

Facts about Diphenhydramine as a treatment option for Insomnia

A

A large body of evidence

Consistently superior to placebo in terms of induction of sleep, using 50mg ON

50mg is as effective as 60mg sodium pentobarbital.

No increase in effectiveness over 50mg

ADRs – antimuscarinic, additive sedation

Do not use in: glaucoma, prostatic enlargement

TREATMENT OF CHOICE

27
Q

Diphenhydramine is contraindicated in what kind of condition?

A

Do not use in glaucoma, prostatic enlargement

28
Q

What is the brand name of Diphenhydramine?

A

Nytol

29
Q

State the dosage of Diphenhydramine 50mg tablets

A

Adult dose - Over 16; 1 tablet taken 20 mins before bed

30
Q

Is Diphenhydramine recommended for under 16years old?

A

Children (under 16) not recommended

31
Q

State the dosage of 25mg Diphenhydramine tablet.

A

Diphenhydramine 25mg tablets
(Adult dose - Over 16) - 2 tablets taken 20 mins before bed
Children (under 16) - not recommended

32
Q

Facts about Promethazine

A

Widely accepted but only 1 trial found
Adam and Oswald (1986) – 12 healthy volunteers, placebo or 20 or 40mg Promethazine
Both doses increased length of sleep and reduced sleep disturbances cf placebo
Not clear if statistically significant.
Same ADRs / CI as Diphenhydramine

33
Q

What is the brand name of Promethazine?

A

Sominex

34
Q

What is dosage for 20mg Promethazine tablet?

A
Promethazine 20mg tablets
Adult dose (over 16) – One tablet at bedtime
Child dose (under 16) – not recommended
35
Q

List the herbal products available for the treatment of insomnia

A
Valeriana officinalis
Hops (NOT beer though!!!)
Wild lettuce – powdered extract
Passionflower –leaves, flowers  & fruit
Lemon balm - leaves
Lavender - flowers
Jamaica dogwood – root bark
36
Q

Facts about Valerian

A

Many trials, not all easy to compare so meta-analysis is difficult

Most show subjective improvement in patients perception of insomnia

Often patients state that their insomnia is ‘much improved’

Not much hard evidence

One trial shows similar effects to low-dose Oxazepam.

.

37
Q

List the ADRs of Valerian

A

Hepatotoxicity and impairment

38
Q

State the dosage of Valerian used for the treatment of Insomnia

A

Blend of Valerian, Hops, and Passionflower

2 tablets one hour before bedtime

39
Q

Facts about Hypnotics

A
Prescribers must weigh up risk vs. benefit
Rx only in short-term cases
1 or 2 doses may suffice in these cases
 BNF – Limit course to 2-4 weeks max
Intermittent ( every 3 nights) dosing
Tolerance develops within 14 days!!
40
Q

Facts about Benzodiazepines

A

Act on GABA by binding to benzodiazepine receptors, boosting inhibitory action of GABA.
CSM warning to only use when insomnia is severe, disabling and causing stress
Do change sleep ‘type’
reducing REM sleep – associated with dreaming.
Seems to reduce quality

41
Q

when should Benzodiazepines be used in the treatment of Insomnia according to CSM?

A

CSM warning to only use when insomnia is severe, disabling, and causing stress

42
Q

List examples of short-acting benzodiazepines?

A

Temazepam, Lorazepam

43
Q

List examples of Long-acting Benzodiazepines

A

Nitrazepam

44
Q

State the dosage of Temazepam

A

Temazepam: 10-40 mg ON

45
Q

What is the dose of Temazepam in elderly patients?

A

10mg for elderly (20mg exceptionally

46
Q

Temazepam. is recommended in children. True/false?

A

True

47
Q

What kind of effect is seen in patients on Short-acting Benzodiazepines?

A

little hangover effect

48
Q

Benzodiazepine is a CD schedule …..

A

3

49
Q

List the ADRs of Benzodiazepines

A

Drowsiness, light-headedness, Confusion, ataxia, amnesia, dependence

50
Q

Facts about Z- drugs?

A

Zopiclone, Zolpidem, Zalepon
Non-benzodiazepines, but act on GABA
Short duration of action
ADRS – Similar to Benzodiazepines PLUS tremors, libido changes
Perceived by Psychiatrists to cause less dependence than Benzodiazepines (Pharm J 11/5/2002)
More expensive than Benzodiazepines

51
Q

Facts about Hypnotic withdrawal programme

A

Transfer to equivalent diazepam dose
Reduce dose every 2/52, in 2-2.5 mg stages
Stop for a while if symptoms start
Reduce in smaller steps if needed near end of process
Stop completely
Timescale: 4 weeks to 1 year !