INR and Warfarin Flashcards
1
Q
Warfarin
A
anticoagulant
2
Q
indications for use
A
mechanical valves
second line management in AF and VTE
3
Q
can it be used during pregnancy and breast-feeding
A
not in pregnancy but safe in breastfeeding
4
Q
what can reduce the INR value
A
antiepileptics - phenytoin, carbamazepine
barbiturate
chronic alcohol intake
smoking
5
Q
what can increase the INR value
A
anti-epileptics - sodium valproate acute alcohol intake allopurinol SSRI amiadorone
6
Q
management of high INR
A
major bleeding:
stop warfarin
give IV vit K
minor bleeding >8 stop warfarin give IV vit K repeat if still high after 24hrs start warfarin when <5
no bleeding > 8 stop warfarin give oral vit K repeat if still high after 24hrs start warfarin when <5
minor bleeding INR 5-8
stop warfarin
give IV vit K
start warfarin when <5
no bleeding INR 5-8
reduce number of doses of warfarin
