Innate Immunity- First lines of defense

Question 1

From the blood plasma (and on cell membranes), these proteins combat microbes by opsonizing microbes, inducing positive chemotaxis for phagocytes to find microbes more easily, and lysing cells by incorporation of MACs into microbial membranes

Answer 1

Complement proteins

Question 2

One of 3 lymphocytes derived from the lymphoid cell line and makes up 5-10% of all lymphocytes. They attack any cell displaying abnormal plasma membrane proteins releasing granules that either perforate the membrane of the target cell or induce infected target cells to undergo apoptosis

Answer 2

Natural Killer Cells

Question 3

One of the fixed macrophages, embedded in the extremely abundant loose areolar C.T. of the body

Answer 3

Histiocytes

Question 4

Random assortment of proteins with a broad spectrum of antimicrobial activity

Answer 4

Antimicrobial proteins (dermcidin, cathelicidin, thrombocidin, defensin)

Question 5

Derived from monocytes, huge phagocytes that travel to the site of infection and go on rampant eating sprees

Answer 5

Wandering macrophages

Question 6

One of the fixed macrophages, within the neural tissue of the brain parenchymal

Answer 6

Microglial cells

Question 7

Secreted by lymphocytes, macrophages, and fibroblasts infected by viruses. In paracrine fashion, IFs go to neighboring cells and allow for the production of molecules that prevent further viral reproduction in neighboring cells

Answer 7

Interferons

Question 8

One of the fixed macrophages, found inside the alveoli of the lungs

Answer 8

Alveolar macrophages

Question 9

Most plentiful phagocytes that reach sites of infection first. They non-specifically phagocytose a ton of microbes at the site of infection

Answer 9

Neutrophils

Question 10

Just doing their job in the body, they sequester free iron for their own purposes, thereby limiting available iron for extensive microbial proliferation

Answer 10

Iron-binding proteins (transferrin, ferritin, hemoglobin)