Influenza Flashcards

1
Q

Genoma de las influenzas

A

ssRNA

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2
Q

Envueltos o desnudos

A

Envueltos

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3
Q

Dónde sucede la transcripción?

A

Intranuclear (RdRp)

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4
Q

Cómo se transmite la influenza A

A

Animales
- Aves
- Cerdos
- Murciélagos

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5
Q

Cómo se clasifica la influenza A

A

Por sus glucoproteínas
- Hemaglutina: H1
- Neuraminidasa: N1

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6
Q

Hemaglutina qué hace?

A

Entrada a la célula
- Anticuerpos conrta ella

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7
Q

Neuraminidasa

A
  • Enzima
  • Libera viriones
  • Destruye moco
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8
Q

Antigenic drift qué es?

A

Mutaciones puntuales acumuladas = nuevas cepas

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9
Q

Antigenic shift qué es?

A

Segmento completo se intercambia entre dos virus (sólo pasa en A) = Pandemia

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10
Q

Influenza B

A
  • Exclusiva en humanos
  • Clasificación por el lugar
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11
Q

Influenza C

A

Raramente causan enfermedad

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12
Q

Transmisión

A

Por gotas y superficies
- Puede ser antes de tener síntomas
- Niños son gran fuente de transmisión

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13
Q

Qué infectan?

A
  • Vía aérea superior = destruyen cilios = tos
  • Epitelio: Sobreinfección por bacterias
  • Secretoras de moco
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14
Q

Enfermedades extrapulmonares

A
  • Miocitis
  • Meningitis
  • Hepatitis
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15
Q

Diagnóstico

A
  • Tamizaje
  • PCR
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16
Q

Tratamiento

A
  • Inhiben NA
  • Inhiben M2 (sólo influenza A)
  • Inhibidor de Pol.
  • Vacunación anual