Helicobácter Flashcards

1
Q

Cómo son?

A

Bacilos espirales
- Se ve cocoide en cultivos viejos

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2
Q

Gram

A

negativos

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3
Q

Qué colonizan?

A
  • Estómago (gástricos)
  • Intestinos (Enteropáticos)
    Crónico
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4
Q

Qué les da la movilidad?

A

Flagelos

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5
Q

Cuál es su principal factor de virulencia?

A

Producen ureasa (neutraliza el ácido = microambiente)

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6
Q

Son postitivos para:

A

Catalasa y Oxidasa

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7
Q

Patogenia

A

Lesiones causadas por productos de
- ureasa
- mucinasas
- Citotoxina
- Gen cagA

Bloquea la producción de ácido gástrico

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8
Q

Qué hace la ureasa?

A

Produce amonio=menos acidez)

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9
Q

Qué hacen las mucinas?

A

Atraviesa el moco para llegar al epitelio
- Si hay mucha, se destruye el moco y se hace una úlcera

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10
Q

Qué hace el gen cagA?

A

Forma estructuras como jeringas que injecta la prot. cagA = producción de IL-8

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11
Q

Enfermedades que causa

A
  • Gastroenteritis
  • Gastritis
    • De aguda pasa a crónica (epitelio fibroso)
    • Pueden salir úlceras pépticas
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12
Q

Diagnóstico

A
  • Examenes histológicos (microscopía)
  • Pruebas de ureasa
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13
Q

Por qué no se remueven?

A

Porque protegen contra el ERGE

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14
Q

Tratamiento

A

Sólo sintomáticos
- Amoxiciclina + claritromicina + Inhibidor de bomba de protones (omeprazol)

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