Inflammation / Healing Process - 1 Flashcards
overuse, cyclic loading, friction injuries. small stresses that cause injury over time
microtrauma
large injury that results in failure of musculoskeletal structures
macrotrauma
primary injury can cause swelling and ultrastructural changes like damaging the blank of the ankle
ligaments
two causes of secondary injury
enzymatic injury, metabolic injury
example of an enzymatic secondary injury
lysosomal mechanism (eating good tissue)
example of metabolic injury
inadequate waste removal
inflammation is a coordinated chemical response with blank
vascularity
heat and redness are caused by increased blank
vascularity
swelling is caused by blockage of blank drainage
lymphatic
pain is caused by a physical blank or blank irritation
pressure, chemical
loss of function is caused by blank
pain/swelling
activate blank receptors with joint mobes to inhibit blank receptors
mechano, pain
blood clotting aka
hemostasis
protective –> controlled motion –> return to function
aka inflammation, proliferation, maturation
vasoconstriction in injured vessels is the blank response to injury
vascular
protein rich fluid escapes into surrounding tissue which pulls blank with it due to being blank
water, hydrophilic
pressure exerted by a column of water
hydrostatic pressure
pressure resulting from attraction of fluid by free proteins
osmotic pressure
basophils, eosinophils, neutrophils are all pretty important in blank
inflammation
release antibodies into bloodstream
b lymphocytes
cell deprived of oxygen
hypoxia
when hypoxia occurs in cells after injury, blank metabolism kicks in, so the blank pump slows down which increases cellular blank
anaerobic, sodium potassium, acidosis
removal of noxious stimuli, growth of capillary beds, collagen forms, easily injured tissue
proliferation phase
fibroblasts produce blank
collagen
fibroblast growth occurring in connective tissue
fibroplasia
composed of capillaries, fibroblasts, and myofibroblasts
granulation tissue
initially type blank collagen is formed
3
wound contraction that pulls epithelial layer inwards
myofibroblasts
wound closure takes about blank days in muscle/skin
5-8
wound closure takes blank days in tendon and ligament
3-6 weeks
wound contraction begins about blank days after injury
5
growth of new blood vessels during proliferation
angiogenesis
longest phase in healing process and can last more than a year
maturation
goal of maturation pt
return to normal funciton
collagen provides extracellular blank
framework
synthesis of scar dominates over lysis will result in blank or blank scars
hypertrophic, keloid
a red scar means more blank is occurring
healing
restarting acute phase without getting out of it
recurrent inflammation
healing where scar tissue restores normal function
acceptable
healing where injury is more likely
minimal
healing where no tissue is really repaired
failed
collagen goes from type 3 to type 1 during this healing phase
maturation
tendon healing is only blank to blank
minimal, acceptable
inflammation occurs in blank tissue
vascularized
capillary filtration pressure formula
(CHP + TOP) - (THP + COP)
CHP is
capillary hydrostatic pressure
top is
tissue osmotic pressure
thp is
tissue hydrostatic pressure
cop is
capillary osmotic pressure
