Inflammation and Wound Healing Flashcards
2 examples of noxious effects of inflammation
- Fever
2. Pulmonary TB elicits protective tissue reaction that can erode pulmonary vessels…causing bleeding
Can inflammation occur post mortem?
No, inflammation can only occur in living tissue
Name 5 signs of inflammation
- Heat
- Redness
- Swelling
- Pain
- Loss of function
What is the body’s first response to injury?
change in blood flow
What accounts for the redness, swelling and warmth at the beginning of inflammation
smooth muscle on precapillary arterioles relaxes allowing more blood to flow into the effected area
What is the first response of arterioles to injury which is folled by vasodilation and relation of precapillary arterioles?
First response is vasocontriction for a few seconds
Name for when WBC marginate to the sides of a blood vessel
pavementing
What WBC is most prevalent in acute inflammation
neutrophils
How long do neutrophils last before being replaced by other WBCs?
2-4 days
Which WBC replace neutrophils after they’ve completed their life span
- macrophages
- lymphocytes
- plasma cells
When plasma leaks through blood vessels, higher blood concentration will cause RBC to do what?
Rouleaux formation, which will impede and slow down flow in the area of inflammation even more
Name the 4 steps of emigration of Leukocytes
- Adhesion of PMN to endothelium
- Insertion of cutoplasmic pseudopods between the junctions of the endothelial cells
- Passage between basement membrane
- Ameboid movement away from vessel toward the cause of inflammation
Adhesion molecules found both on leukocytes and endothelial lining are activated by what?
interleukins
Name 3 sources of chemoattractants for PMN (polymorphonuclear leukocytes)
- Bacteria
- Tissues destroyed by inflammation
- Activated complement
Attachment of PMC to bacteria (how it is recognized as foreign) is facilitated by _____ and _______
immunoglobulins, and complement (C3)
