Diseases of the Breast

Question 1

What is the most common inflammatory disease of the breast?

Answer 1

Acute mastitis

Question 2

What is the cause of fat necrosis of the breast?

Answer 2

History of trauma (prior surgery, or radiation)

Question 3

Gross appearance of fat necrosis of the breast

Answer 3

Early: hemorrhage with central fat necrosis
Later: nodule of gray-white firm tissue with foci of chalk-white debris

Question 4

Estrogen and Progesterone stimulate the proliferation of cells (epithelial hyperplasia) in excretory ducts of the breast and intralobar stroma

Answer 4

Fibrocystic Change of the breast

Question 5

Fibrocystic change of the breast

Answer 5

1. Fibrosis + blue-domed cysts
2. Hormone related
3. Epithelial hyperplasia in the excretory ducts and intralobar stroma
4. “Bag of worms”
5. Bilateral

Question 6

Is fibrocystic change of the breast associated with breast cancer?

Answer 6

Only if epithelial hyperplasia becomes multilayered

Question 7

Most common benign breast tumor

Answer 7

Fibroadenoma

Question 8

Fibroadenoma

Answer 8

• Encapsulated
• moveable
• easily removable
• upper outer quadrant
• Fibrous stroma and glandular epithelium

Question 9

• Serous of bloody discharge from nipple
• Inside lactiferous ducts
• small mass under the nipple

Answer 9

Intraductal papilloma

Question 10

2nd most common cancer in women

Answer 10

carcinoma of the breast (#1 is lung)

Question 11

When is radiation therapy used in carcinoma of the breast?

Answer 11

advanced cancer

Question 12

Name the two non-invasive carcinomas of the breast

Answer 12

1. Intraductal

2. Lobular (in situ)

Question 13

Lobular carcinoma (in situ)

Answer 13

• cells proliferate in terminal ducts
• Bilateral
• can be seen near invasive carcinomas

Question 14

Name the 4 invasive breast carcinomas

Answer 14

1. Ductal
2. Lobular carcinoma
3. Medullary Carcinoma
4. Colloid or Mucinous Carcinoma

Question 15

Which breast cancer is associated with a desmoplastic reaction?

Answer 15

Ductal carcinoma

Question 16

Paget’s disease of the breast is a ductal carcinoma affecting which part of the breast?

Answer 16

nipple and areolar areas

-Large clear cells located in epidermis

Question 17

Are lobular carcinomas unilateral or bilateral?

Answer 17

Lobular = bilateral

Question 18

Histology: single file rows of malignant tumor cells and targetoid pattern around ducts

Answer 18

Lobular carcinoma

Question 19

Large flesh tumor (>5cm) with foci of hemorrhage and necrosis and marked lymphocytic infiltrate

Answer 19

Medullary carcinoma

Question 20

slow growing carcinoma found in older women. Tumor is soft and gelatinous.

Histology: large gray-blue lakes of mucin and small island of neoplastic cells floating in the mucin

Answer 20

Colloid or mucinous carcinoma

Question 21

Causes of gynecomastia in men

Answer 21

• cirrhosis

- tumors causing excess estrogen