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Inflammation Flashcards

1
Q

mediators of vasodilation

A

PGI, PGE, PGD

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2
Q

mediators of vasoconstriction

A

thromboxane A2, LTC4, LTD4, LTE4

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3
Q

mediators of increased vascular permeability

A

LTC4, LTD4, LTE4

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4
Q

mediators of chemotaxis and leukocyte adhesion

A

LTB4, HETE (precursor to LTs)

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5
Q

source of histamine

A

mast cells
basophils
platelets

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6
Q

action of histamine

A

vasodilation
increased vascular permeability
endothelial activation

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7
Q

source of prostaglandins

A

mast cells

leukocytes

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8
Q

actions of prostaglandins

A

vasodilation
pain
fever

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9
Q

source of leukotrienes

A

mast cells

leukocytes

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10
Q

actions of leukotrienes

A

increased vascular permeability
chemotaxis
leukocyte adhesion
activation

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11
Q

source of cytokines

A

macrophages
endothelial cells
mast cells

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12
Q

action of cytokines

A

endothelial activation
fever
metabolic abnormalities
hypotension

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13
Q

source of chemokines

A

leukocytes

activated macrophages

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14
Q

source of platelet-activating factor

A

leukocytes

mast cells

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15
Q

actions of platelet-activating factor

A 
vasodilation
increased vascular permeability
leukocyte adhesion
chemotaxis
degranulation
oxidative burst
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16
Q

source of compliment

A

plasma (liver)

17
Q

actions of complement

A

leukocyte chemotaxis/ activation
MAC complex
vasodilation

18
Q

source of kinins

A

plasma (liver)

19
Q

actions of kinins

A

increased vascular permeability
smooth muscle contraction
vasodilation
pain

20
Q

cytokines of acute inflammation

A 
TNF
IL-1
IL-6
Chemokines
IL-17
21
Q

Chemokines of chronic inflammation

A

IL-12
INF-y
IL-17

22
Q

sources of TNF

A

macrophages
mast cells
T lymphocytes

23
Q

actions of TNF

A

stimulates expression of endothelial adhesion molecules and secretions of other cytokines, systemic effects

24
Q

sources of IL-1

A

macrophages
endothelial cells
epithelial cells

25
Q

actions of IL-1

26
Q

sources of IL-6

A

macrophages

27
Q

actions of IL-6

A

acute phase reactant

28
Q

source of chemokines

A

macrophages
endothelial cells
T lymphocytes
mast cells

29
Q

actions of chemokines

A

recruitment of leukocytes to sites of inflammation

migration od cells into normal tissues

30
Q

source of IL-17

A

T lymphocytes

31
Q

action of IL-17

A

recruitment of neutrophils and monocytes

32
Q

source of IL-12

A

dendritic cells

macrophages

33
Q

actions of IL-12

A

increased production of IFN-y

34
Q

source of IFN-y

A

T lymphocytes

NK cells

35
Q

actions of IFN-y

A

activation of macrophages to kill microbes and tumor cells

Pathology (18 decks)

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