Hypersensitivities Flashcards
Autoimmune Hemolytic Anemia
Target:
Mechanism:
Hypersensitivity Type:
Target: Rh blood group antigens
Mechanism: Opsonization and phagocytosis of erythrocytes
Hypersensitivity Type: Type 2
Autoimmune Idiopathic Thrombocytopenic Purpura
Target:
Mechanism:
Hypersensitivity Type:
Target: gpIIb/gpIIIa integrin/ platelet membrane proteins
Mechanism: Opsonization and phagocytosis of platelets
Hypersensitivity Type: Type 2
Goodpasture syndrome Autoantibody: Target: Mechanism: Hypersensitivity Type:
Autoantibody: anti-glomerular basement menbrane
Target: noncollagenous proteins in the basement membrane of glomeruli and lung alveoli
Mechanism: complement and Fc receptor-mediated inflammation
Hypersensitivity Type: Type 2
Myasthenia Gravis Autoantibody: Target: Mechanism: Hypersensitivity Type:
Autoantibody: Anti-ACh receptor
Target: AChR
Mechanism: antibody inhibits ACh binding and down modulates receptors
Hypersensitivity Type: Type 2
Graves Disease Autoantibody: Target: Mechanism: Hypersensitivity Type:
Autoantibody: Anti-TSH receptor
Target: TSH receptor
Mechanism: antibody-mediated stimulation of TSH receptors
Hypersensitivity Type: Type 2
Pemphigus vulgaris Autoantibody: Target: Mechanism: Hypersensitivity Type:
Autoantibody: anti-desmoglein/ anti-desmosome
Target: desmoglein in intracellular junctions of epidermal cells
Mechanism: antibody-mediated activation of proteases and disruption of cellular adhesions
Hypersensitivity Type: Type 2
Pernicious Anemia Autoantibody: Target: Mechanism: Hypersensitivity Type:
Autoantibody: anti-parietal cell and anti-IF
Target:intrinsic factor
Mechanism: neutralization of intrinsic factor, decreased absorption of B12
Hypersensitivity Type: Type 2
Rheumatic Fever
Target:
Mechanism:
Hypersensitivity Type:
Target: antibody cross-reacts with myocardial antigen
Mechanism: Inflammation and macrophage activation
Hypersensitivity Type: Type 2
SLE Autoantibody: Target: Manifestations: Hypersensitivity Type:
Autoantibody: Anti-dsDNA, Anti-cardiolipin, Anti-smith, ANA
Target: DNA, neucleoproteins
Manifestations: nephritis, arthritis, vasculitis, butterfly facial rash
Hypersensitivity Type: Type 3
Polyarteritis nodosa
Target:
Manifestations:
Hypersensitivity Type:
Target: microbial antigens/ unknown
Manifestations: vasculitis
Hypersensitivity Type: Type 3
Poststreptococcal Glomerulonephritis
Target:
Manifestations:
Hypersensitivity Type:
Target: strep cell wall antigens
Manifestations: nephritis with lumpy bumpy deposits
Hypersensitivity Type: type 3
Serum Sickness
Target:
Manifestations:
Hypersensitivity Type:
Target: various protein antigens
Manifestations: systemic vasculitis, nephritis, arthritis
Hypersensitivity Type: Type 3
Arthus Reaction
Target:
Manifestations:
Hypersensitivity Type:
Target: various protein antigens
Manifestations: local cutaneous vasculitis
Hypersensitivity Type: Type 3
Multiple Sclerosis
Target:
Manifestations:
Hypersensitivity Type:
Target: myelin basic protein
Manifestations: demyelination in CNS with sensory and motor dysfunction
Hypersensitivity Type: Type 4
Rheumatoid Arthritis Autoantibody: Target: Manifestations: Hypersensitivity Type:
Autoantibody: anti-CCP and rheumatoid factor
Target: joint antigens
Manifestations: inflammation of synovium and erosion of cartilage and bone in joints
Hypersensitivity Type: Type 4
DM Type 1 Autoantibody: Target: Manifestations: Hypersensitivity Type:
Autoantibody: anti-glutamic acid decarboxylase, islet cell cytoplasmic antibodies
Target: pancreatic islet antigens
Manifestations: impaired glucose metabolism, vascular disease
Hypersensitivity Type: Type 4
Crohns Disease
Target:
Manifestations:
Hypersensitivity Type:
Target: unknown
Manifestations: inflamed bowel with abd pain diarrhea and hemorrhage
Hypersensitivity Type: Type 4
PPD skin test
Target:
Manifestations:
Hypersensitivity Type:
Target: bacterial antigen
Manifestations: indurated skin lesion
Hypersensitivity Type: Type 4
Viral Hepatitis Autoantibody: Target: Manifestations: Hypersensitivity Type:
Autoantibody: anti-smooth muscle
Target: virally encoded proteins
Manifestations: CTL-mediated hepatocyte death, liver dysfunction, fibrosis
Hypersensitivity Type: Type 4
Contact Dermatitis
Target:
Manifestations:
Hypersensitivity Type:
Target: skin allergens
Manifestations: vascular lesion,s pruritic rash
Hypersensitivity Type: Type 4
Hashimoto Thyroiditis Autoantibody: Target: Manifestations: Hypersensitivity Type:
Autoantibody: Anti-microsomal, anti-thyroglobin, anti-thyroid peroxidase
Target: thyroid antigens
Manifestations: hypothyroidism
Hypersensitivity Type: Type 4
Guillain Barre
Target:
Manifestations:
Hypersensitivity Type:
Target: peripheral nerve myelin or gangliosides
Manifestations: ascending paralysis
Hypersensitivity Type: Type 4
Celiac Disease Autoantibody: Target: Manifestations: Hypersensitivity Type:
Autoantibody: IgA anti-endomysial, IgA anti-tissue translutaminase, IgA and IgG deaminated gliadin peptide
Target: gliadin and HLA class 1 molecules
Manifestations: gluten-sensitive enteropathy
Hypersensitivity Type: Type 4
