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Pathology > Hypersensitivities > Flashcards

Hypersensitivities Flashcards

1
Q

Autoimmune Hemolytic Anemia
Target:
Mechanism:
Hypersensitivity Type:

A

Target: Rh blood group antigens
Mechanism: Opsonization and phagocytosis of erythrocytes
Hypersensitivity Type: Type 2

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2
Q

Autoimmune Idiopathic Thrombocytopenic Purpura
Target:
Mechanism:
Hypersensitivity Type:

A

Target: gpIIb/gpIIIa integrin/ platelet membrane proteins
Mechanism: Opsonization and phagocytosis of platelets
Hypersensitivity Type: Type 2

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3
Q 
Goodpasture syndrome
Autoantibody:
Target:
Mechanism:
Hypersensitivity Type:
A

Autoantibody: anti-glomerular basement menbrane
Target: noncollagenous proteins in the basement membrane of glomeruli and lung alveoli
Mechanism: complement and Fc receptor-mediated inflammation
Hypersensitivity Type: Type 2

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4
Q 
Myasthenia Gravis
Autoantibody:
Target:
Mechanism:
Hypersensitivity Type:
A

Autoantibody: Anti-ACh receptor
Target: AChR
Mechanism: antibody inhibits ACh binding and down modulates receptors
Hypersensitivity Type: Type 2

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5
Q 
Graves Disease
Autoantibody:
Target:
Mechanism:
Hypersensitivity Type:
A

Autoantibody: Anti-TSH receptor
Target: TSH receptor
Mechanism: antibody-mediated stimulation of TSH receptors
Hypersensitivity Type: Type 2

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6
Q 
Pemphigus vulgaris
Autoantibody:
Target:
Mechanism:
Hypersensitivity Type:
A

Autoantibody: anti-desmoglein/ anti-desmosome
Target: desmoglein in intracellular junctions of epidermal cells
Mechanism: antibody-mediated activation of proteases and disruption of cellular adhesions
Hypersensitivity Type: Type 2

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7
Q 
Pernicious Anemia
Autoantibody:
Target:
Mechanism:
Hypersensitivity Type:
A

Autoantibody: anti-parietal cell and anti-IF
Target:intrinsic factor
Mechanism: neutralization of intrinsic factor, decreased absorption of B12
Hypersensitivity Type: Type 2

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8
Q

Rheumatic Fever
Target:
Mechanism:
Hypersensitivity Type:

A

Target: antibody cross-reacts with myocardial antigen
Mechanism: Inflammation and macrophage activation
Hypersensitivity Type: Type 2

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9
Q 
SLE
Autoantibody:
Target:
Manifestations:
Hypersensitivity Type:
A

Autoantibody: Anti-dsDNA, Anti-cardiolipin, Anti-smith, ANA
Target: DNA, neucleoproteins
Manifestations: nephritis, arthritis, vasculitis, butterfly facial rash
Hypersensitivity Type: Type 3

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10
Q

Polyarteritis nodosa
Target:
Manifestations:
Hypersensitivity Type:

A

Target: microbial antigens/ unknown
Manifestations: vasculitis
Hypersensitivity Type: Type 3

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11
Q

Poststreptococcal Glomerulonephritis
Target:
Manifestations:
Hypersensitivity Type:

A

Target: strep cell wall antigens
Manifestations: nephritis with lumpy bumpy deposits
Hypersensitivity Type: type 3

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12
Q

Serum Sickness
Target:
Manifestations:
Hypersensitivity Type:

A

Target: various protein antigens
Manifestations: systemic vasculitis, nephritis, arthritis
Hypersensitivity Type: Type 3

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13
Q

Arthus Reaction
Target:
Manifestations:
Hypersensitivity Type:

A

Target: various protein antigens
Manifestations: local cutaneous vasculitis
Hypersensitivity Type: Type 3

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14
Q

Multiple Sclerosis
Target:
Manifestations:
Hypersensitivity Type:

A

Target: myelin basic protein
Manifestations: demyelination in CNS with sensory and motor dysfunction
Hypersensitivity Type: Type 4

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15
Q 
Rheumatoid Arthritis
Autoantibody:
Target:
Manifestations:
Hypersensitivity Type:
A

Autoantibody: anti-CCP and rheumatoid factor
Target: joint antigens
Manifestations: inflammation of synovium and erosion of cartilage and bone in joints
Hypersensitivity Type: Type 4

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16
Q 
DM Type 1
Autoantibody:
Target:
Manifestations:
Hypersensitivity Type:
A

Autoantibody: anti-glutamic acid decarboxylase, islet cell cytoplasmic antibodies
Target: pancreatic islet antigens
Manifestations: impaired glucose metabolism, vascular disease
Hypersensitivity Type: Type 4

17
Q

Crohns Disease
Target:
Manifestations:
Hypersensitivity Type:

A

Target: unknown
Manifestations: inflamed bowel with abd pain diarrhea and hemorrhage
Hypersensitivity Type: Type 4

18
Q

PPD skin test
Target:
Manifestations:
Hypersensitivity Type:

A

Target: bacterial antigen
Manifestations: indurated skin lesion
Hypersensitivity Type: Type 4

19
Q 
Viral Hepatitis
Autoantibody:
Target:
Manifestations:
Hypersensitivity Type:
A

Autoantibody: anti-smooth muscle
Target: virally encoded proteins
Manifestations: CTL-mediated hepatocyte death, liver dysfunction, fibrosis
Hypersensitivity Type: Type 4

20
Q

Contact Dermatitis
Target:
Manifestations:
Hypersensitivity Type:

A

Target: skin allergens
Manifestations: vascular lesion,s pruritic rash
Hypersensitivity Type: Type 4

21
Q 
Hashimoto Thyroiditis
Autoantibody:
Target:
Manifestations:
Hypersensitivity Type:
A

Autoantibody: Anti-microsomal, anti-thyroglobin, anti-thyroid peroxidase
Target: thyroid antigens
Manifestations: hypothyroidism
Hypersensitivity Type: Type 4

22
Q

Guillain Barre
Target:
Manifestations:
Hypersensitivity Type:

A

Target: peripheral nerve myelin or gangliosides
Manifestations: ascending paralysis
Hypersensitivity Type: Type 4

23
Q 
Celiac Disease
Autoantibody:
Target:
Manifestations:
Hypersensitivity Type:
A

Autoantibody: IgA anti-endomysial, IgA anti-tissue translutaminase, IgA and IgG deaminated gliadin peptide
Target: gliadin and HLA class 1 molecules
Manifestations: gluten-sensitive enteropathy
Hypersensitivity Type: Type 4

Pathology (18 decks)

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