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2nd U2 Pharm > Inflammation > Flashcards

Inflammation Flashcards

1
Q

What is the mechanism of action of acetylsalicylic acid?

A

irreversibly acetylares COX-1 and 2

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2
Q

What salicylate drug reversible inhibits COX 1 and 2 and is a metabolite of acetylsalicylic acid?

A

Salicylic acid

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3
Q

What is acetylsalicylic acid used for?

A

Antiplatelet
analgesic
antipyretic

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4
Q

What are side effects of acetylsalicylic acid?

A

GI irritation
Bleeding and anemia
hepatotoxicity
salicylate toxicity

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5
Q

What is the mechanism of action of the salicylate, diflunisal?

A

Reversibly inhibits COX1 and 2

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6
Q

What is diflunisal used for?

A

osteoarthritis
MSK strains/sprains
Pain after dental extraction
Postepisiotomy pain

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7
Q

What are the side effects of diflunisal?

A

Fewer GI side effects and less effect on platelets than aspirin

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8
Q

What class is acetaminophen in?

A

para-amino phenol

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9
Q

What is the mechanism of action of acetaminophen?

A

Reversibly inhibits COX-1 and 2

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10
Q

Used as an analgesic and antipyretic similar to aspirin, but has a weak anti-inflammatory effect?

A

Acetaminophen

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11
Q

What are the side effects of acetaminophen?

A

Renal tubular necrosis if chronically abused with other NSAIDs
Hepatic necrosis with overdose

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12
Q

What is the toxic intermediate of acetaminophen?

A

N-acetyl-benzoquinoneimine

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13
Q

What are the 2 indole drugs that reversibly inhibit COX 1 and 2 and are used to treat RA, ankylosing spondylitis, OA and acute gout?

A

Indomethacin

Sulindac

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14
Q

What are the side effects seen with the 2 indoles (indomethacin and sulindac)?

A

Thrombocytopenia
aplastic anemia
severe frontal HA

Nephrotoxicity in elderly or hypovolemic pts

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15
Q

What are the 4 propionic acid derivatives that reversibly inhibit COX 1 and 2 and are used to treat rheumatic disorders, OA, ankylosing spondylitis, postpartum pain, dysmenorrhea pain, and many types of surgeries?

A

Ibuprofen
Flurbiprofen
Naproxen
Oxaprozin

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16
Q 
What are the side effects of the propionic acid derivatives?
Ibuprofen
Flurbiprofen
Naproxen
Oxaprozin
A

GI irritation

Hepatotoxicity

17
Q

What has a longer t 1/2 than most propionic acid derivatives?

A

Naproxen (13 hrs)

18
Q

What has a much longer t 1/2 than most propionic acid derivatives?

A

Oxaprozin (50hrs)

19
Q

What class is piroxicam in?

A

Enolic acid

20
Q

What is the mechanism of action of piroxicam?

A

Reversibly inhibits COX-1 and 2

21
Q

What is piroxicam used for?

A

long-term treatment of RA or OA

Also ankylosing spondylitis, acute MSK disorders, acute gout

22
Q

What are the two heteroaryl acetic acids that reversibly inhibit COX 1 and 2?

A

Ketorolac

Diclofenac

23
Q

What are the uses of ketorolac?

A

Post-op pain

Inflammatory eye conditions

24
Q

What are the uses of diclofenac?

A

Long-term treatment of RA or OA

Also ankylosing spondylitis and migraines

25
Q

What are the 2 COX-2 inhibitors that have the same anti-inflammatory, antipyretic, and analgesic effects as NSAIDs, but have less GI toxicity?

A

Celocoxib

Etoricoxib

26
Q

The 2 COX-2 inhibitors are contraindicated in patients with________.

A

Heart problems

Pregnancy

2nd U2 Pharm (9 decks)

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