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2nd U2 Pharm > Adrenergic Receptor Agonists/Antagonists > Flashcards

Adrenergic Receptor Agonists/Antagonists Flashcards

1
Q

What are the 2 non-selective adrenergic receptor agonists?

A

Norepinephrine

Epinephrine

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2
Q

What is norepinephrine an agonist for?

A

a1
a2
B1

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3
Q

What is epinephrine an agonist for?

A

a1
a2
B1
B2

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4
Q

Name the indirect acting adrenergic receptor agonist…

A

Amphetamine

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5
Q

What is the mechanism of action for amphetamine?

A

Increases release of NE

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6
Q

What class does isoproterenol fall in?

A

Non-selective B agonist

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7
Q

What is isoproterenol an agonist for?

A

B1

B2

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8
Q

What class does dobutamine fall in?

A

B1-selective B agonist

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9
Q

What is dobutamine an agonist for?

A

B1

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10
Q

What class does albuterol fall in?

A

B2-selective B agonist

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11
Q

What is albuterol an agonist for?

A

B2

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12
Q

What class does terbutaline fall in?

A

B2-selctive B agonist

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13
Q

What is terbutaline an agonist for?

A

B2

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14
Q

Non-selective agonist used for acute hypotension

A

NE

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15
Q

Non-selective agonist used for anaphylactic shock; also combined with local anesthetics and used to treat glaucoma…

A

Epi

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16
Q

Indirect acting adrenergic receptor agonist used for the treatment of ADHD, narcolepsy, recreation

A

Amphetamine

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17
Q

What are the side effects of NE?

A

HTN
arrhythmia
headache

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18
Q

What are the side effects of EPI?

A

Palpitation
arrhythmias
headache

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19
Q

What are the side effects of amphetamine?

A

HTN
insomnia
anxiety
arrhythmias

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20
Q

Non-selective B agonist used for the treatment of shock, and heart block…

A

Isoproterenol

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21
Q

B1-selective B agonist used for the treatment of cardiac decompensation, shock, and heart block…

A

Dobutamine

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22
Q

B2-selective B agonist used to prevent or reverse exercise-induced bronchospasm; mild asthma; COPD…

A

Albuterol

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23
Q

B2-selective B agonist used to prevent or reverse exercise-induced bronchospasm; mild asthma; COPD and early labor…

A

Terbutaline

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24
Q

What are the side effects of isoproterenol?

A

Palpitation
Tachyarrhythmia
headache

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25
Q

What are the side effects of dobutamine?

A

Tachyarrythmias

HTN

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26
Q

Albuterol and terbutaline can potentially mask what?

A

Progressively severe inflammation

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27
Q

What are the side effects of albuterol and terbutaline?

A

Tachycardia

Muscle tremor

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28
Q

a1-selective a agonist..

A

Phenylephrine

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29
Q

What is phenylephrine an agonist for?

A

a1

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30
Q

What are the 2 a2-selective a agonists?

A

Clonidine

a-methyldopa

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31
Q

What is the mechanism of action for clonidine?

A

CNA a2 agonist

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32
Q

What is the mechanism of action for a-methyldopa?

A

Metabolite (a-methylnorepinephrine) activates CNS a2 receptors

33
Q

What is phenylephrine used for?

A

Nasal congestion

postural hypotension

34
Q

What is clonidine used for?

A

HTN
Shock
Drug withdrawal

35
Q

What is a-methyldopa used for?

A

HTN

36
Q

What are the side effects of phenylephrine?

A

HTN

Reflex bradycardia

37
Q

What are the side effects of clonidine and a-methyldopa?

A

Sedation

38
Q

a2-selective a agonist that can cross the BBB and is a prodrug…

A

a-methyldopa

39
Q

Selective dopamine agonist…

A

Fenoldopam

40
Q

What is fenoldopam an agonist for?

A

D1 only

41
Q

Mixed acting (direct/indirect) adrenergic receptor agonist…

A

Dopamine

42
Q

What is dopamine and agonist for?

A

D1–low dose (direct)
a1–high dose (direct with some indirect (NE))
B1–med dose (direct with some indirect (NE))

43
Q

What is Fenoldopam used for?

A

Increase blood flow at renal, mesenteric and cerebral arteries

44
Q

What is dopamine used for?

A

Shock
Renal failure
Hypotension

45
Q

What is the side effect of dopamine?

A

Vasoconstriction at high doses

46
Q

Name the 2 non-selective a-antagonists…

A

Phentolamine

Phenoxybenzamine

47
Q

What is phentolamine an antagonist for?

A

a1

a2

48
Q

What is phenoxybenzamine an antagonist for?

A

a1
a2

non-competitive blocker–covalently bind receptor

49
Q

What are the non-selective a-antagonist drugs, phentolamine and phenoxybenzamine, used for?

A

Pheochromocytoma
Raynaud’s
Frostbite

50
Q

What are the side effects of all the a-antagonists?

A

Postural hypotension

51
Q

What are the side effects of the non-selective a-antagonists?

A

Postural hypotension

Inhibit ejaculation

52
Q

Name the 2 a1-selective antagonist…

A

Prazosin

Terazosin

53
Q

What are the uses of Prazosin and Terazosin?

A

Primary HTN

BPH

54
Q

Name the 2 non-selective B antagonist (1st generation)

A

Propranolol

Timolol

55
Q

What are propranolol and timolol antagonist for?

A

B1

B2

56
Q

What non-selective B antagonist is used to treat angina, HTN, and arrhythmias?

A

Propranolol

57
Q

What are the side effects of propranolol and timolol?

A

Bradycardia
Bronchoconstriction
Sexual dysfunction

58
Q

Non-selective B antagonist used to treat glaucoma…

A

Timolol

59
Q

Name the 3 2nd generation B1-selective antagonists…

A

Metoprolol
Atenolol
Bisoprolol

60
Q

What are all 3 2nd generation B1-selective antagonists used to treat? (Metoprolol, Atenolol, Bisoprolol)

A

HTN
Angina
Arrhythmias
CHF

61
Q

What are the side effects of all 3 2nd generation B1-selective antagonists? (Metoprolol, Atenolol, Bisoprolol)

A

Bradycardia

sexual dysfunction

62
Q

What are the 2 3rd generation “A” non-selective B antagonists?

A

Carvedilol

Labetalol

63
Q

What are all the 3rd generation B antagonists used for?

A

CHF

HTN

64
Q

What are the side effects of the 2 3rd generation “A” non-selective B antagonists? (Carvedilol and Labetalol)

A

Bradycardia

Fatigue

65
Q

Name the 3rd generation “B” B1 selective antagonist…

A

Betaxolol

66
Q

What is betaxolol used for?

A

CHF

HTN

67
Q

What are the side effects of Betaxolol?

A

Bradycardia

68
Q

What is the indirect acting adrenergic receptor agonist, which works through increasing cytoplasmic NE release?

A

Tyramine

69
Q

A drug that prevents NE re-uptake and is used as a local anesthetic and vasoconstrictor?

A

Cocaine

70
Q

What are the side effects of cocaine?

A

Insomnia
Anxiety
Arrhythmias

71
Q

Name the 3 nerve ending blockers…

A

Guanethidine
Reserpine
a-me-tyrosine

72
Q

What is the mechanism for guanethidine?

A

False NT–causing vesicles to become full of guanethidine rather than NE

73
Q

What is guanethidine used for?

A

antihypertensive

74
Q

What isn’t Guanethidine used?

A

Many and serious side effects

unable to cross BBB

75
Q

Nerve ending blocker that causes release of empty vesicles by it binds the re-uptake transporter and stops NE from reentry…

A

Reserpine

76
Q

What is reserpine used for?

A

it is an old antiHTN

77
Q

What is the mechanism for a-me-tyrosine, a nerve ending blocker?

A

Inhibits tyrosine hydroxylase–decreasing NE synthesis

78
Q

What is a-me-tyrosine used for?

A

treatment of pheochromocytoma

79
Q

Mixed, direct B2/indirect agonist used for nasal decongestion and anorexia?

A

Ephedrine

2nd U2 Pharm (9 decks)

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