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2nd U2 Pharm > Dermatopharmacology > Flashcards

Dermatopharmacology Flashcards

1
Q

Steroid used for dermatitis and psoriasis?

A

Hydrocortisone

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2
Q

What are the major side effects seen with steroid use?

A 
Atrophy/thinning of skin
stretch marks
talangiectasias
acne
cataract or glaucoma if applied near eye
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3
Q

What systemic effect is seen with steroid use?

A

affects hypothalamic-pituitary-adrenal axis–> growth retardation

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4
Q

Seven classes of steroids exist. What class is the strongest and which is the weakest?

A 
class I--> strongest
class VII--> weakest
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5
Q

What immunosuppressant is used for the treatment of inflammatory conditions (psoriasis)?

A

Cyclosporine

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6
Q

What are the side effects of cyclosporine?

A

Raises BP

Damage to kidneys with long-term use

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7
Q

What folate analog is used for the treatment of inflammatory conditions (psoriasis)?

A

Methotrexate

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8
Q

What is the mechanism of action for methotrexate?

A

Inhibits DHFR

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9
Q

What are the major side effects seen with methotrexate?

A

Hepatotoxicity
pulmonary fibrosis
leukopenia
rarely, renal toxicity

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10
Q

Drugs used to block TNF-a in order to treat inflammatory conditions?

A

Biologics

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11
Q

What are the side effects of biologics?

A

Few

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12
Q

What is the mechanism of action of UV light therapy?

A

Immunosuppression of T-cells via type I or type II reactios

mono- or bifunctional adducts in DNA

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13
Q

What is UV light therapy used to treat?

A 
Inflammatory conditions
atopic dermatitis
CTCL
lichen Plans
psoriasis
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14
Q

What are the major side effects of UV light therapy?

A

Skin cx

Thinning/leathering skin

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15
Q

What sensitize the skin to UV light therapy?

A

Usually used with psoralens–increases efficacy

Phenothiazines, thiazides, sulfonamides, NSAIDs, tetracycline, benzodiazapenes also sensitize skin to light therapy

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16
Q

What is the mechanism of action for the retinoids?

A

Stimulate epithelial cell turnover and are also anti-inflammatory

17
Q

What retinoid is used for the treatment of acne?

A

Isotretinoin

18
Q

What retinoid is used for the treatment of psoriasis?

A

Acitretin

19
Q

What are the side effects of the retinoids?

A

Teratogenic effects

20
Q

What dermatopharmacologic agent is good as adjunct to other therapies?

A

Retinoids

2nd U2 Pharm (9 decks)

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