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2nd U2 Pharm > Cholinergic Receptor inhibitors > Flashcards

Cholinergic Receptor inhibitors Flashcards

1
Q

Name the 6 tertiary amine antimuscarinic drugs that block muscarinic receptors…

A 
Atropine
Scopolamine
Dicyclomine
Tropicamide
Tolterodine
Benztropine
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2
Q

What is the mechanism of action for Atropine?

A

Blocks muscarinic receptors

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3
Q

What is the mechanism of action for Scopolamine?

A

Blocks muscarinic receptors

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4
Q

What is the mechanism of action for Dicyclomine?

A

Blocks muscarinic receptors

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5
Q

What is the mechanism of action for Tropicamide?

A

Blocks muscarinic receptors

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6
Q

What is the mechanism of action for Tolterodine?

A

Blocks muscarinic receptors

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7
Q

What is the mechanism of action for Benztropine?

A

Blocks muscarinic receptors

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8
Q

What is atropine used for?

A

Mydriasis and cycloplegia

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9
Q

What is scopolamine used for?

A

Prevent or reduce motion sickness

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10
Q

What is dicyclomine used for?

A

Reduce transient hypermotility

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11
Q

What is tropicamide used for?

A

Mydriasis and cycloplegia

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12
Q

What is tolterodine used for?

A

Treat transient cystitis; post-op bladder spasms and incontinence

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13
Q

What is benztropine used for?

A

Treat manifestations of Parkinson’s disease

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14
Q

What are the side effects of all the cholinergic receptor inhibitors that block the muscarinic receptors?

A

General block of muscarinic functions

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15
Q

Which tertiary amine crosses the BBB?

A

Benztropine

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16
Q

Name the 3 Quaternary amine antimuscarinic drugs?

A

Glycopyrrolate
Ipratropium
Tiotropium

17
Q

What is the mechanism of action of all 3 quaternary amine antimuscarinic drugs? (Glycopyrrolate, Ipratropium, Tiotropium)

A

Blocks muscarinic receptors

18
Q

Which quaternary amine antimuscarinic drug is used to reduce transient hypermotility?

A

Glycopyrrolate

19
Q

What 2 quaternary amine antimuscarinic drugs are used to bronchodilate in asthma or COPD?

A

Ipratropium

Tiotropium

20
Q

What are the 2 cholinergic receptor inhibitors that a ganglionic blockers?

A

Hexamethonium

Mecamylamine

21
Q

What is the mechanism of action of hexamethonium and mecamylamine?

A

Blocks ganglionic (Nn) receptor and sympathetic tone

22
Q

Which of the cholinergic receptor inhibitors is a depolarizing blocker?

A

Succinylcholine

23
Q

What is the mechanism of action for succinylcholine?

A

Overstimulation of nicotinic receptor–leading to desensitization of muscle unit to further ACh stimulation

24
Q

Name the two non depolarizing cholinhergic receptor inhibitors…

A

Tubocurarine

Mivacurium

25
Q

What is the mechanism of action of tubocurarine and mivacurium?

A

Blocks nicotinic (Nm) receptor

26
Q

Which cholinergic receptor inhibitor is a local paralytic drug that blocks vesicle fusion and ACh release on presynaptic terminal?

A

Botulinum Toxin A

27
Q

What does Botulinum Toxin A degrade in order to cause its effect?

A

SNAP-25

28
Q

What two cholinergic receptor inhibitors are used for a hypertensive crisis, “bloodless” field surgery?

A

Hexamethonium

Mecamylamine

29
Q

What is succinylcholine used for?

A

Brief procedures–tracheal intubation, reset dislocated joints

30
Q

What two cholinergic receptor inhibitors are used for muscle relaxant for surgery w/o deep anesthesia?

A

Tubocurarine

Mivacurium

31
Q

Cholinergic receptor inhibitor used to reduce frown lines and wrinkles; achalasia; strabismus; oromandibular dystonia…

A

Botulinum toxin A

32
Q

What are the side effects seen with the depolarizing and non-depolarizing blockers?

A

Respiratory paralysis; disturbance of autonomic function

33
Q

Which cholinergic receptor inhibitor drug produces flaccid paralysis within 1 minute?

A

Succinylcholine

2nd U2 Pharm (9 decks)

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