Cholinergic Receptor inhibitors Flashcards
Name the 6 tertiary amine antimuscarinic drugs that block muscarinic receptors…
Atropine Scopolamine Dicyclomine Tropicamide Tolterodine Benztropine
What is the mechanism of action for Atropine?
Blocks muscarinic receptors
What is the mechanism of action for Scopolamine?
Blocks muscarinic receptors
What is the mechanism of action for Dicyclomine?
Blocks muscarinic receptors
What is the mechanism of action for Tropicamide?
Blocks muscarinic receptors
What is the mechanism of action for Tolterodine?
Blocks muscarinic receptors
What is the mechanism of action for Benztropine?
Blocks muscarinic receptors
What is atropine used for?
Mydriasis and cycloplegia
What is scopolamine used for?
Prevent or reduce motion sickness
What is dicyclomine used for?
Reduce transient hypermotility
What is tropicamide used for?
Mydriasis and cycloplegia
What is tolterodine used for?
Treat transient cystitis; post-op bladder spasms and incontinence
What is benztropine used for?
Treat manifestations of Parkinson’s disease
What are the side effects of all the cholinergic receptor inhibitors that block the muscarinic receptors?
General block of muscarinic functions
Which tertiary amine crosses the BBB?
Benztropine
Name the 3 Quaternary amine antimuscarinic drugs?
Glycopyrrolate
Ipratropium
Tiotropium
What is the mechanism of action of all 3 quaternary amine antimuscarinic drugs? (Glycopyrrolate, Ipratropium, Tiotropium)
Blocks muscarinic receptors
Which quaternary amine antimuscarinic drug is used to reduce transient hypermotility?
Glycopyrrolate
What 2 quaternary amine antimuscarinic drugs are used to bronchodilate in asthma or COPD?
Ipratropium
Tiotropium
What are the 2 cholinergic receptor inhibitors that a ganglionic blockers?
Hexamethonium
Mecamylamine
What is the mechanism of action of hexamethonium and mecamylamine?
Blocks ganglionic (Nn) receptor and sympathetic tone
Which of the cholinergic receptor inhibitors is a depolarizing blocker?
Succinylcholine
What is the mechanism of action for succinylcholine?
Overstimulation of nicotinic receptor–leading to desensitization of muscle unit to further ACh stimulation
Name the two non depolarizing cholinhergic receptor inhibitors…
Tubocurarine
Mivacurium
What is the mechanism of action of tubocurarine and mivacurium?
Blocks nicotinic (Nm) receptor
Which cholinergic receptor inhibitor is a local paralytic drug that blocks vesicle fusion and ACh release on presynaptic terminal?
Botulinum Toxin A
What does Botulinum Toxin A degrade in order to cause its effect?
SNAP-25
What two cholinergic receptor inhibitors are used for a hypertensive crisis, “bloodless” field surgery?
Hexamethonium
Mecamylamine
What is succinylcholine used for?
Brief procedures–tracheal intubation, reset dislocated joints
What two cholinergic receptor inhibitors are used for muscle relaxant for surgery w/o deep anesthesia?
Tubocurarine
Mivacurium
Cholinergic receptor inhibitor used to reduce frown lines and wrinkles; achalasia; strabismus; oromandibular dystonia…
Botulinum toxin A
What are the side effects seen with the depolarizing and non-depolarizing blockers?
Respiratory paralysis; disturbance of autonomic function
Which cholinergic receptor inhibitor drug produces flaccid paralysis within 1 minute?
Succinylcholine
