Cholinergic Receptor inhibitors

Question 1

Name the 6 tertiary amine antimuscarinic drugs that block muscarinic receptors…

Answer 1

Atropine
Scopolamine
Dicyclomine
Tropicamide
Tolterodine
Benztropine

Question 2

What is the mechanism of action for Atropine?

Answer 2

Blocks muscarinic receptors

Question 3

What is the mechanism of action for Scopolamine?

Answer 3

Blocks muscarinic receptors

Question 4

What is the mechanism of action for Dicyclomine?

Answer 4

Blocks muscarinic receptors

Question 5

What is the mechanism of action for Tropicamide?

Answer 5

Blocks muscarinic receptors

Question 6

What is the mechanism of action for Tolterodine?

Answer 6

Blocks muscarinic receptors

Question 7

What is the mechanism of action for Benztropine?

Answer 7

Blocks muscarinic receptors

Question 8

What is atropine used for?

Answer 8

Mydriasis and cycloplegia

Question 9

What is scopolamine used for?

Answer 9

Prevent or reduce motion sickness

Question 10

What is dicyclomine used for?

Answer 10

Reduce transient hypermotility

Question 11

What is tropicamide used for?

Answer 11

Mydriasis and cycloplegia

Question 12

What is tolterodine used for?

Answer 12

Treat transient cystitis; post-op bladder spasms and incontinence

Question 13

What is benztropine used for?

Answer 13

Treat manifestations of Parkinson’s disease

Question 14

What are the side effects of all the cholinergic receptor inhibitors that block the muscarinic receptors?

Answer 14

General block of muscarinic functions

Question 15

Which tertiary amine crosses the BBB?

Answer 15

Benztropine

Question 16

Name the 3 Quaternary amine antimuscarinic drugs?

Answer 16

Glycopyrrolate
Ipratropium
Tiotropium

Question 17

What is the mechanism of action of all 3 quaternary amine antimuscarinic drugs? (Glycopyrrolate, Ipratropium, Tiotropium)

Answer 17

Blocks muscarinic receptors

Question 18

Which quaternary amine antimuscarinic drug is used to reduce transient hypermotility?

Answer 18

Glycopyrrolate

Question 19

What 2 quaternary amine antimuscarinic drugs are used to bronchodilate in asthma or COPD?

Answer 19

Ipratropium

Tiotropium

Question 20

What are the 2 cholinergic receptor inhibitors that a ganglionic blockers?

Answer 20

Hexamethonium

Mecamylamine

Question 21

What is the mechanism of action of hexamethonium and mecamylamine?

Answer 21

Blocks ganglionic (Nn) receptor and sympathetic tone

Question 22

Which of the cholinergic receptor inhibitors is a depolarizing blocker?

Answer 22

Succinylcholine

Question 23

What is the mechanism of action for succinylcholine?

Answer 23

Overstimulation of nicotinic receptor–leading to desensitization of muscle unit to further ACh stimulation

Question 24

Name the two non depolarizing cholinhergic receptor inhibitors…

Answer 24

Tubocurarine

Mivacurium

Question 25

What is the mechanism of action of tubocurarine and mivacurium?

Answer 25

Blocks nicotinic (Nm) receptor

Question 26

Which cholinergic receptor inhibitor is a local paralytic drug that blocks vesicle fusion and ACh release on presynaptic terminal?

Answer 26

Botulinum Toxin A

Question 27

What does Botulinum Toxin A degrade in order to cause its effect?

Answer 27

SNAP-25

Question 28

What two cholinergic receptor inhibitors are used for a hypertensive crisis, "bloodless" field surgery?

Answer 28

Hexamethonium | Mecamylamine

Question 29

What is succinylcholine used for?

Answer 29

Brief procedures--tracheal intubation, reset dislocated joints

Question 30

What two cholinergic receptor inhibitors are used for muscle relaxant for surgery w/o deep anesthesia?

Answer 30

Tubocurarine | Mivacurium

Question 31

Cholinergic receptor inhibitor used to reduce frown lines and wrinkles; achalasia; strabismus; oromandibular dystonia...

Answer 31

Botulinum toxin A

Question 32

What are the side effects seen with the depolarizing and non-depolarizing blockers?

Answer 32

Respiratory paralysis; disturbance of autonomic function

Question 33

Which cholinergic receptor inhibitor drug produces flaccid paralysis within 1 minute?

Answer 33

Succinylcholine