inflammation 2

Question 1

list an example of a leukotriene receptor antagonist

Answer 1

Montelukast

Question 2

an example of a lipoxygenase inhibitor is

Answer 2

Zileuton

Question 3

TNF is also produced by T lymphocytes and mast cells
T or F

Answer 3

T

Question 4

IL-1 is produced by some epithelial cells as well
T or F

Answer 4

T

Question 5

The production of TNF is induced by signals through microbial sensors such as?

Answer 5

Toll like receptors

Question 6

what cytokine activates fibroblasts to synthesize collagen and stimulates proliferation of synovial and other mesenchymal cells?

Answer 6

il - 1

Question 7

what cytokine regulates energy balance by promoting lipid and protein mobilization and by suppressing appetite

Answer 7

TNF tissue necrosis factor

Question 8

cachexia and anorexia that accompanies some chronic inflammation is due to overproduction of ?

Answer 8

TNF

Question 9

list 2 inflammatory disease that TNF antagonist are used in the treatment

Answer 9

Rheumatoid arthritis
psoriasis

Question 10

Tnf antagonist are not as effective as il-1 antagonist in treating inflammatory disease
T or F

Answer 10

F
il-1 antagonist are not as effective as Tnf antagonist

Question 11

epithelial cells can produce il-1
T or F

Answer 11

T
it dey slide

Question 12

C-X-C chemokines act primarily on what immune cell

Answer 12

neutrophils

Question 13

the most important inducers of il-8 are

Answer 13

microbial products
il-1 and TNF

Question 14

list 3 examples of C-C chemokines

Answer 14

MCP-1 (monocyte chemoattractant protein)
eotaxin
MIP-1a
RANTES

Question 15

the only member of CX3C chemokines is

Answer 15

Fractalkine

Question 16

list the two main functions of chemokines

Answer 16

increasing the affinity of integrins
stimulate migration (chemotaxis) of leukocytes in tissues.

Question 17

chemokines produced in normal tissues are called

Answer 17

homeostasic chemokines

Question 18

example of c chemokines

Answer 18

lymphotactin

Question 19

The critical step in complement activation is

Answer 19

proteolysis of C3
c3 is the third and most abundant component of the complement system

Question 20

The classical pathway is initiated by

Answer 20

binding of C1 to antibody (either igG or igM) that has combined with antigen

Question 21

The alternative pathway is triggered by

Answer 21

microbial surface molecule e.g endotoxin in the absence of antibody

Question 22

The lectin pathway is activated by

Answer 22

binding of plasma mannose binding lectin to carbohydrates present on microbes then directly activates C1

Question 23

the three complement activation pathway lead to the formation of what enzyme

Answer 23

C3 convertase
c3 convertase splits C3 into two functionally distinct fragments, C3a and C3b

Question 24

How is c5 convertase formed

Answer 24

binding of covalentlly bonded c3b at the site of complement activation to more c3b fragments

Question 25

what is the function of c5 convertase

Answer 25

cleaves C5 to release C5a and leave C5b attached to the cell surface

Question 26

what is the function of c5b

Answer 26

C5b binds the late components (C6-C9), culminating in the formation of the membrane attack complex

Question 27

the membrane attack complex is composed of what complement

Answer 27

composed of multiple C9 molecules

Question 28

what complement proteins stimulate histamine release from mast cells

Answer 28

C3a, C5a, and, to a lesser extent, C4a

Question 29

c5a is a chemotactic agent for neutrophils, monocytes, eosinophils, and basophils T or F

Answer 29

T check page 27 inflammation 2 slide

Question 30

c5a activates what arachidonic acid metabolism pathway

Answer 30

lipoxygenase pathway

Question 31

the main function of the complement protein MAC is to

Answer 31

cause cell lysis mac means membrane attack complex

Question 32

what is the most important inhibitor of complement activation

Answer 32

C1 inhibitor

Question 33

deficiency of c1 inhibitor presents pathologically as

Answer 33

hereditary angiodema

Question 34

Decay accelerating factor (DAF) inhibits formation of

Answer 34

c3 convertase

Question 35

CD59 inhibits formation of

Answer 35

membrane attack complex

Question 36

Decay accelerating factor (DAF) and CD59 are linked to plasma membranes by

Answer 36

glycophosphatidyl (GPI) anchor