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Morbid > inflammation 2 > Flashcards

inflammation 2 Flashcards

1
Q

list an example of a leukotriene receptor antagonist

A

Montelukast

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2
Q

an example of a lipoxygenase inhibitor is

A

Zileuton

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3
Q

TNF is also produced by T lymphocytes and mast cells
T or F

A

T

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4
Q

IL-1 is produced by some epithelial cells as well
T or F

A

T

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5
Q

The production of TNF is induced by signals through microbial sensors such as?

A

Toll like receptors

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6
Q

what cytokine activates fibroblasts to synthesize collagen and stimulates proliferation of synovial and other mesenchymal cells?

A

il - 1

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7
Q

what cytokine regulates energy balance by promoting lipid and protein mobilization and by suppressing appetite

A

TNF tissue necrosis factor

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8
Q

cachexia and anorexia that accompanies some chronic inflammation is due to overproduction of ?

A

TNF

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9
Q

list 2 inflammatory disease that TNF antagonist are used in the treatment

A

Rheumatoid arthritis
psoriasis

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10
Q

Tnf antagonist are not as effective as il-1 antagonist in treating inflammatory disease
T or F

A

F
il-1 antagonist are not as effective as Tnf antagonist

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11
Q

epithelial cells can produce il-1
T or F

A

T
it dey slide

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12
Q

C-X-C chemokines act primarily on what immune cell

A

neutrophils

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13
Q

the most important inducers of il-8 are

A

microbial products
il-1 and TNF

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14
Q

list 3 examples of C-C chemokines

A

MCP-1 (monocyte chemoattractant protein)
eotaxin
MIP-1a
RANTES

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15
Q

the only member of CX3C chemokines is

A

Fractalkine

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16
Q

list the two main functions of chemokines

A

increasing the affinity of integrins
stimulate migration (chemotaxis) of leukocytes in tissues.

17
Q

chemokines produced in normal tissues are called

A

homeostasic chemokines

18
Q

example of c chemokines

A

lymphotactin

19
Q

The critical step in complement activation is

A

proteolysis of C3
c3 is the third and most abundant component of the complement system

20
Q

The classical pathway is initiated by

A

binding of C1 to antibody (either igG or igM) that has combined with antigen

21
Q

The alternative pathway is triggered by

A

microbial surface molecule e.g endotoxin in the absence of antibody

22
Q

The lectin pathway is activated by

A

binding of plasma mannose binding lectin to carbohydrates present on microbes then directly activates C1

23
Q

the three complement activation pathway lead to the formation of what enzyme

A

C3 convertase
c3 convertase splits C3 into two functionally distinct fragments, C3a and C3b

24
Q

How is c5 convertase formed

A

binding of covalentlly bonded c3b at the site of complement activation to more c3b fragments

25
Q

what is the function of c5 convertase

A

cleaves C5 to release C5a and leave C5b attached to the cell surface

26
Q

what is the function of c5b

A

C5b binds the late components (C6-C9), culminating in the formation of the membrane attack complex

27
Q

the membrane attack complex is composed of what complement

A

composed of multiple C9 molecules

28
Q

what complement proteins stimulate histamine release from mast cells

A

C3a, C5a, and, to a lesser extent, C4a

29
Q

c5a is a chemotactic agent for neutrophils, monocytes, eosinophils, and basophils
T or F

A

T
check page 27 inflammation 2 slide

30
Q

c5a activates what arachidonic acid metabolism pathway

A

lipoxygenase pathway

31
Q

the main function of the complement protein MAC is to

A

cause cell lysis
mac means membrane attack complex

32
Q

what is the most important inhibitor of complement activation

A

C1 inhibitor

33
Q

deficiency of c1 inhibitor presents pathologically as

A

hereditary angiodema

34
Q

Decay accelerating factor (DAF) inhibits formation of

A

c3 convertase

35
Q

CD59 inhibits formation of

A

membrane attack complex

36
Q

Decay accelerating factor (DAF) and CD59 are linked to plasma membranes by

A

glycophosphatidyl (GPI) anchor

Morbid (9 decks)

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