Inflammation Flashcards
1
Q
what causes inflammation?
A
physical chemical insult, infectious agent, antigen
2
Q
what are the clinical features of inflammation?
A
redness, heat, swelling, pain, loss of function
3
Q
what causes redness?
A
vasodilation
4
Q
what causes Heat on the site of inflammation?
A
vasodilation and fever
5
Q
what causes swelling?
A
fluid in the extracellular matrix
6
Q
what causes pain?
A
pain mediators such as bradykinin and serotonin
7
Q
what cells are the first responders to damage?
A
neutrophils
8
Q
what are recruited after neutrophils?
A
macrophages and monocytes
9
Q
how do maturing monocytes work?
A
they phagocytose pathogens and kill then with acidic lysosomes. also important in the repair process and restore tissue homeostasis
10
Q
how are different RAMPS recognised?
A
by TLRs
