Inflamation 2 Flashcards

1
Q

white cell casts

A

nephritis sign. comes out of tubule

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2
Q

histiocytes

A

AKA macrophages

come from monocytes

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3
Q

Giant cells

A

conglomerations of macrophages

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4
Q

asbestos

A

long and needle shaped.

Hemosiderin- iron bearing protein

causes inefective macro response— induce fibrosis.

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5
Q

Lymphocytes

A

..

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6
Q

plasma cells

A

clock faced, eccentric

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7
Q

eosinophil

A

responds to IgE, uses MBP, responds to parasites.

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8
Q

Basophil

A

least common

contain blue granules

IgE coated

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9
Q

Asthma

A

eosinophils^^^^

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10
Q

syphilis

A

spirochetes

skin lesions

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11
Q

TNF-a

A

made by macros, mast, others
activates many cells
prolonged systemic TNF-a causes cachexia

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12
Q

IL-1b

A

made by macros
activates Bcells, CD4 Tcells, endothelial cells
causes fever

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13
Q

Interferon gamme

A

made by lymphos
activates macros
helpful in viral infections

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14
Q

arachidonic acid metabolites

A

crucial inflamatory mediators
cyclooxygenase pathway***- NSAIDS

5-lipooxygenase pathway- leukotrienes

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15
Q

cyclooxygenase pathway

A

NSAIDS and glucocorticoids.

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16
Q

gout

A

chalk like crap in toes, urate crystals.

17
Q

Ki-67

A

proliferation stain, all proliferation

18
Q

types of collagen

A
  1. most abundant
  2. cartilage
  3. soft tissue, early wound healing.
  4. basement membranes
  5. anchoring fibrils to epidermis.
19
Q

steps in tissue healing

A

inflammatory response
clot forms
fibroblasts, endo cells, and pericytes migrate into clot and for granulation.
granulation tissue matures, forming scar.
scar matures, collagen remodeling

20
Q

primary intention

A

.

21
Q

secondary intention

A

.

22
Q

skin healing

A

mixed inflammatory infiltrate with macros, lymphos, polys.

edema, new vessels, fibros

23
Q

problems in tissue repair

A

slow, ~10% in one week
only get up to 75% after months

too much scarring, keloid, desmoids

too little, poor perfusion, steriods, diabetes.
wound dehiscence, cardiac rupture after infarct.

24
Q

dehiscence

A

wound that splits back open.