Inflamation 2 Flashcards
white cell casts
nephritis sign. comes out of tubule
histiocytes
AKA macrophages
come from monocytes
Giant cells
conglomerations of macrophages
asbestos
long and needle shaped.
Hemosiderin- iron bearing protein
causes inefective macro response— induce fibrosis.
Lymphocytes
..
plasma cells
clock faced, eccentric
eosinophil
responds to IgE, uses MBP, responds to parasites.
Basophil
least common
contain blue granules
IgE coated
Asthma
eosinophils^^^^
syphilis
spirochetes
skin lesions
TNF-a
made by macros, mast, others
activates many cells
prolonged systemic TNF-a causes cachexia
IL-1b
made by macros
activates Bcells, CD4 Tcells, endothelial cells
causes fever
Interferon gamme
made by lymphos
activates macros
helpful in viral infections
arachidonic acid metabolites
crucial inflamatory mediators
cyclooxygenase pathway***- NSAIDS
5-lipooxygenase pathway- leukotrienes
cyclooxygenase pathway
NSAIDS and glucocorticoids.