Infections and STDs (2) Flashcards

1
Q

clinical vignette for vulvovaginitis from bacterial vaginosis

A
adherent yellowish discharge; 
pH > 5;
fishy amine odor in KOH;
clue cells; 
gram neg dominate
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2
Q

clinical vignette for vulvovaginitis from Candida spp

A

vulvoaginitis, pruritis; erythema;

discharge w/ consistency of cottage cheese

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3
Q

clinical vignette for vulvovaginitis from Trichomonas vaginalis

A

“Strawberry cervix”;
foamy purulent discharge;
many PMNs and motile trophozoites micro (corkscrew motility)

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4
Q

Pathogenesis of vulvovaginitis from bacterial vaginosis

A

overgrowth of Gardnerella vaginalis;

anaerobes

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5
Q

Pathogenesis of vulvovaginitis from candida spp

A

antibiotic use => overgrowth, immunocompromised

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6
Q

Pathogenesis of vulvovaginitis from trichomonas vaginalis

A

vaginitis w/ discharge

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7
Q

diagnosis of vulvovaginitis from bacterial vaginosis

A

clue cells, gram neg rods

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8
Q

diagnosis of vulvovaginitis from candida spp

A

germ tube test;

gram pos yeasts in vaginal fluids

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9
Q

diagnosis of vulvovaginitis from trichomonas vaginalis

A

pear-shaped trophozoites w/ corckscrew motility

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10
Q

Case vignette and key clues for PID

A

adnexal tenderness, bleeding, dyspareunia;
vaginal discharge, fever;
chandelier sign
onset follows menses

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11
Q

pathogenesis for PID caused by Neisseria gonorrhoeae

A

pili and IgA protease production

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12
Q

pathogenesis for PID caused by chlamydia

A

intracellular in mucosal epithelia;

TYPE 4 HYPERSENSITIVITY DAMAGE

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13
Q

diagnosis for PID caused by Neisseria gonorrhoeae

A

Gram neg diplococci in PMNs;

culture on Thayer Martin

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14
Q

diagnosis for PID caused by Chlamydia tachomatis

A

tissue culture;

intracytoplasmic inclusion bodies in mucosal cells

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15
Q

Case vignette and key clues for Condyloma acuminatum (genital warts)

A

lesions are papillary/wart-like lesions;
may be sessile or pedunculated;
koilocytotic atypica is present;
anogenital

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16
Q

most common cause for condyloma acuminatum (genital warts)

A

HPV

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17
Q

Pathogenesis for condyloma acuminatum (genital warts)

A

HPV proteins E6, E7 inactivate cellular antioncogene;

associated w/ cervical CA

18
Q

Diagnosis for condyloma acuminatum (genital warts)

A

dsDNA, naked, icosahedral;

intranuclear inclusion bodies

19
Q

case vignette or key clues for genital herpes

A

multiple, painful, vesicular, coalescing;

recurring

20
Q

most common cause of genital herpes

A

HSV

21
Q

pathogenesis for genital herpes

A

latent virus in sensory ganglia reactivates

22
Q

Diagnosis fo genital herpes

A
virus culture, intranuclear inclusion bodies;
syncytia (Tzanck smear)
dsDNA enveloped (nuclear), icosahedral
23
Q

case vignette and key clues for primary syphilis

A

painless chancre forms on glans penis (or vulva/cervix) and heals w/in 1-3 months

24
Q

case vignette and key clues for secondary syphilis

A

local or generalized rash lasting 1-3 months;

involves palms and soles

25
Q

case vignette and key clues for tertiary syphilis

A

affects central nervous system, hear and skin;
characteristic lesion is gumma;
single or multiple;
most common in liver, testes, and bone

26
Q

case vignette and key clues for chancroid

A

nonindurated, painful ulcer;
suppurative w/ adenopathy;
slow to heal

27
Q

most common cause of syphilis

A

treponema pallidum

28
Q

most common cause of chancroid

A

haemophius ducreyi

29
Q

case vignette and key clues for lymphogranuloma venereum

A

soft, painless papule heals;
lymph nodes enlarge and develop fistulas;
genital elephantiasis may develop

30
Q

most common cause lymphogranoma venereum

A

chlamydia trachomatis serotypes L1-3

31
Q

Pathogenesis of primary syphilis

A

3 week incubation during which spirochetes spread throughout body

32
Q

pathogenesis of secondary syphilis

A

develops 1-2 months after primary stage

33
Q

pathogenesis of tertiary syphilis

A

develops in 1/3 of untreated patients;
NEUROSYPHILIS =>including meningovascular, tabes dorsalis and general paresis;
obliterative endarteritis of vasa vasorum of aorta can lead thoracic aneurysm

34
Q

pathogenesis of chancroid

A

unknown

35
Q

pathogenesis of lymphogranuloma venereum

A

obligate intracellular

36
Q

Diagnosis of primary syphilis

A

biopsy/scarping viewed w/ dark-field microscopy shows spirillar organisms

37
Q

Diagnosis of secondary syphilis

A

serology => VDRL positive (nonspecific);

FTA-Abs (specific)

38
Q

diagnosis of tertiary syphilis

A

serology=> FTA-abs; non-specific tests may be negative

39
Q

diagnosis of chancroid

A

gram neg rods;

chocolate agar => requires NAD and hemin

40
Q

diagnosis of lymphogranuloma venereum

A

cell culture;

glycogen containing inclusions