Gestational trophoblastic disease Flashcards
tumor of placental trophoblast
Hydatidiform mole (molar pregnancy)
incidence of Hydatidiform mole
1 : 1,000 pregnancies
Clinical setting of Hydatidiform mole
“size greater than dates”; vaginal bleeding, passage of edematous, grape-like tissue;
elevated Beta-hCG;
Where do Hydatidiform mole invade?
invasive moles invade myometrium
Tx for Hydatidiform mole
curettage => follow Beta-hCG levels
What does a complete Hydatidiform mole result from? what makes it up?
fertilization of an ovum that lost all its chromosomal material => ALL CHROMOSOMAL MATERIAL DERIVED FROM SPERM
What is the genotype of a complete Hydatidiform mole?
90% 46, XX;
10% contain a Y
What causes a partial Hydatidiform mole?
fertilization of ovum by 2 sperm => 23, X; 23,Y
Genotype for partial Hydatidiform mole
triploid => 69, XXY (23, X (maternal) + 23X (sperm) + 23Y (2nd sperm))
Define choriocarcinoma in female
MALIGNANT germ cell tumor derived from trophoblast
Gross pathology for choriocarcinoma
necrotic and hemorrhagic mass
micro pathology for choriocarcinoma
proliferation of cytotrophoblasts, intermediate trophoblasts, syncytiotrophoblasts
spread of choriocarcinoma
hematogenous spread to lungs, brain, liver
Tx for choriocarcinoma
responsive to chemo
Difference in Beta-hCG in partial vs complete mole
both elevated but complete mole is very high
