Diseases of ovary Flashcards
Young, obese, hirsute female of reproductive age presents with oligomenorrhea after many unsuccessful months of trying to get pregnant. What is the disease?
polycystic ovary disease => Stein-Leventhal syndrome
What is detectable in the lab results for polycystic ovary disease?
elevated LH; elevated testosterone
low FSH
What is the pathology of polycystic ovary disease?
bilaterally enlarged ovaries w/ multiple follicular cysts
Etiology of polycystic ovary disease
increased LH stimulation leads to increased androgen synthesis and anovulatory cycles
How is polycystic ovary disease Tx?
oral contraceptives or medroxyprogesterone;
surgical wedge resection
What is the most common benign ovarian tumor?
cystadenoma
Name the pathology of cystadenoma
unilocular cyst w/ simple serous or mucinous lining
most common malignant ovarian tumor
cystadeno-carcinoma
How will cystadeno-carcinoma present?
often asymptomatic until far advanced => increased abdominal girth due to ascites, bowel or bladder problems
what does a cystadeno-carcinoma produce
pseudomyxoma peritonei
Lab marker for cystadeno-carcinoma? what else is it used for?
CA-125;
used for response to therapy and recurrence
Gross pathology of cystadeno-carcinoma
complex multiloculated cyst w/ solid areas
Micro pathology of cystadeno-carcinoma
serous or mucinous lining w/ tufting, papillary structures w/ psammoma bodies
How does cystadeno-carcinoma spread?
seedings w/in pelvic cavity
genetic risk factors for cystadeno-carcinoma
BRCA-1 (Breast and ovarian cancers);
Lynch syndrome