Infection: Antimalarials

Question 1

Artemether with lumefantrine is licensed for the treatment of

Answer 1

acute non-complicated falciparum malaria

Question 2

Chloroquine is no longer recommended for the treatment of what? why?

Answer 2

Chloroquine is no longer recommended for the treatment of falciparum malaria owing to widespread resistance, nor is it recommended if the infective species is not known or if the infection is mixed; in these cases treatment should be with quinine, Malarone®, or Riamet®. It is still recommended for the treatment of non-falciparum malaria.

Question 3

Chloroquine is still recommended for the treatment of what?

Answer 3

Chloroquine is no longer recommended for the treatment of falciparum malaria owing to widespread resistance, nor is it recommended if the infective species is not known or if the infection is mixed; in these cases treatment should be with quinine, Malarone®, or Riamet®. It is still recommended for the treatment of non-falciparum malaria.

Question 4

Guidelines for malaria prevention in travellers from the United Kingdom (2017) published by Public Health England state that patients already taking _______________for another indication, and for whom chloroquine would be an appropriate antimalarial, can remain on _____________ sulfate.

Answer 4

Guidelines for malaria prevention in travellers from the United Kingdom (2017) published by Public Health England state that patients already taking hydroxychloroquine sulfate for another indication, and for whom chloroquine would be an appropriate antimalarial, can remain on hydroxychloroquine sulfate.

Question 5

Mefloquine is used for the prophylaxis of malaria in areas of the world where there is a high risk of what?

Answer 5

Mefloquine is used for the prophylaxis of malaria in areas of the world where there is a high risk of chloroquine-resistant falciparum malaria

Question 6

In malaria treatment, what is the purpose of primaquine use?

Answer 6

Primaquine is used to eliminate the liver stages of P. vivax or P. ovale following chloroquine treatment.

Question 7

Proguanil hydrochloride used alone is not suitable for the treatment of malaria; however, Malarone® (a combination of ________ with proguanil hydrochloride) is licensed for the treatment of acute uncomplicated falciparum malaria.

Answer 7

Proguanil hydrochloride used alone is not suitable for the treatment of malaria; however, Malarone® (a combination of atovaquone with proguanil hydrochloride) is licensed for the treatment of acute uncomplicated falciparum malaria.

Question 8

Why is Malarone particularly suitable for short trips to highly chloroquine-resistant areas?

Answer 8

Malarone® is particularly suitable for short trips to highly chloroquine-resistant areas because it needs to be taken only for 7 days after leaving an endemic area.

Question 9

When is quinine used for the treatment of falciparum malaria?

Answer 9

Quinine is used for the treatment of falciparum malaria or if the infective species is not known or if the infection is mixed

Question 10

Doxycycline is used in adults and children over __ years for the prophylaxis of malaria in areas of widespread mefloquine or chloroquine resistance. Doxycycline is also used as an alternative to mefloquine or Malarone®

Answer 10

Doxycycline is used in adults and children over 12 years for the prophylaxis of malaria in areas of widespread mefloquine or chloroquine resistance. Doxycycline is also used as an alternative to mefloquine or Malarone®