Endocrine: Exocrine pancreatic insufficiency Flashcards
Exocrine pancreatic insufficiency is characterised by reduced secretion of pancreatic enzymes into
Exocrine pancreatic insufficiency is characterised by reduced secretion of pancreatic enzymes into the duodenum.
The main clinical manifestations are maldigestion and malnutrition, associated with low circulating levels of micronutrients,__-____ ______ and lipoproteins
The main clinical manifestations are maldigestion and malnutrition, associated with low circulating levels of micronutrients, fat-soluble vitamins and lipoproteins.
Patients with exocrine pancreatic insufficiency also present with
Patients also present with gastro-intestinal symptoms such as diarrhoea, abdominal cramps and steatorrhoea.
What can cause exocrine pancreatic insufficiency?
Exocrine pancreatic insufficiency can result from chronic pancreatitis, cystic fibrosis, obstructive pancreatic tumours, coeliac disease, Zollinger-Ellison syndrome, and gastro-intestinal or pancreatic surgical resection.
What is Zollinger-Ellison syndrome?
a condition in which a gastrin-secreting tumour or hyperplasia of the islet cells in the pancreas causes overproduction of gastric acid, resulting in recurrent peptic ulcers.
What is the mainstay of treatment for exocrine pancreatic insufficiency?
Pancreatic enzyme replacement therapy with pancreatin is the mainstay of treatment for exocrine pancreatic insufficiency.
Pancreatin contains what?
Pancreatin contains the three main groups of digestive enzymes: lipase, amylase and protease.
When should pancreatin be administered?
Pancreatin should be administered with meals and snacks. The dose should be adjusted, as necessary, to the lowest effective dose according to the symptoms of maldigestion and malabsorption.
Manufacturers of Pancrease HL® and Nutrizym 22® recommend that the total dose of pancreatin used in patients with cystic fibrosis should not usually exceed ______units/kg/day of lipase.
Manufacturers of Pancrease HL® and Nutrizym 22® recommend that the total dose of pancreatin used in patients with cystic fibrosis should not usually exceed 10 000 units/kg/day of lipase.
Manufacturers of pancreatin recommend that if a patient taking pancreatin develops new abdominal symptoms (or any change in existing abdominal symptoms) the patient should be reviewed to exclude what?
Manufacturers of pancreatin recommend that if a patient taking pancreatin develops new abdominal symptoms (or any change in existing abdominal symptoms) the patient should be reviewed to exclude the possibility of colonic damage.
What dietary advice is there for people requiring pancreatin?
Food intake should be distributed between three main meals per day, and two or three snacks. Food that is difficult to digest should be avoided, such as legumes (peas, beans, lentils) and high-fibre foods. Alcohol should be avoided completely. Reduced fat diets are not recommended.
