Infecção Flashcards
Qual o local mais comum do osso de ocorrer osteomielite na criança? Por quê?
The relative absence of phagocytic cells in the metaphyses of bones in children may explain why acute hematogenous osteomyelitis is more common in this location.
Quais fatores dependentes do paciente estão relacionados ao desenvolvimento da osteomielite?
Patient-dependent factors include nutrition, immunological status, and infection at a remote site.
Quanto de energia um evento traumático ou um processo infeccioso aumenta o metabolismo basal?
Basal energy requirements of a traumatized or infected patient increase from 30% to 55% of normal.
Como pode ser avaliado o status nutricional de um paciente?
Nutritional status can be determined preoperatively by (1) anthropometric measurements (height, weight, triceps skin fold thickness, and arm muscle circumference), (2) measurement of serum proteins or cell types (lymphocytes), and (3) antibody reaction to certain antigens in skin testing. Nutritional support is recommended before elective surgery for patients with recent weight losses of more than 10 lb, serum albumin levels less than 3.4 g/dL or lymphocyte counts of less than 1500 cells/mm.
Qual a formula do cálculo nutricional?
[(1.2 × serum albumin) + (0.013 × serum transferrin)] − 6.43. If the sum is 0 or a negative number, the patient is nutritionally depleted and is at high risk for sepsis.
Quais são os principais mecanismos de defesa do organismo?
The body’s main defense mechanisms are (1) neutrophil response, (2) humoral immunity, (3) cell-mediated immunity, and (4) reticuloendothelial cells.
A quais tipos de bacterias está sujeito um paciente com diminuição da imunidade humoral e mediada por células?
Abnormal neutrophils or humoral and cell-mediated immunities have been implicated in infections caused by encapsulated bacteria in infants and elderly patients, in the increased incidence of Pseudomonas infections in heroin addicts, and in Salmonella and Pneumococcus infections in patients with sickle cell anemia.
Quais doenças diminuem a contagem de neutrófilos?
Diabetes, alcoholism, hematological malignancy, and cytotoxic therapy are common causes of neutrophil abnormalities.
A partir de que niveis de neutrofilos o paciente fica susceptível a infecções? Quais são os germes?
If the neutrophil count decreases to less than 55/mm3 , infections caused by Staphylococcus aureus, gram-negative bacilli, Aspergillus organisms, and Candida organisms become a major threat.
Pacientes com hipogamaglobulinemia e esplenectomizados estão sujeitos a infecção por qual tipo de bacterias?
Patients with hypogammaglobulinemia or who have had a splenectomy are at increased risk of infection caused by encapsulated bacteria, such as Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria organisms. Septic arthritis caused by unusual organisms such as Mycoplasma pneumoniae and Ureaplasma urealyticum has been reported and should be suspected in patients with hypogamma- globulinemia and culture-negative septic arthritis.
Paciente com deficiencia no sistema complemento estão sujeito a infecção por quais organismos?
When a defect in a component of the complement cascade is present, S. aureus and gram-negative bacillus infections are common.
Quais fatores podem levar a uma deficiencia secundária da imunidade mediada por células? A quais organismos o paciente está sujeito à infecção?
Corticosteroid therapy, malnutrition, lymphoma, systemic lupus erythematosus, immunodeficiency in elderly patients, and autoimmune deficiency syndrome all can cause a secondary cell-mediated deficiency, which predisposes the host to fungal and mycobacterial infections and also infection with herpesvirus and Pneumocystis jiroveci.
Em qual local da pele geralmente as bactérias residem e se reproduzem?
the hair follicles and sebaceous glands where bacteria normally reside and reproduce.
Quais dedos geralmente são perfurados durante o ato cirurgico?
Most frequently, the perforation occurs on the index finger or thumb of the nondominant hand.
De quanto em quanto tempo as luvas cirurgicas devem ser trocadas durante uma cirurgia?
At a minimum, surgical gloves should be changed every 2 hours.
O fluxo de ar laminar na sala de cirurgia diminui em quanto a porcentagem de bactérias suspensas no ar?
Airborne bacterial concentrations in the operating room may be reduced by at least 80% with laminar-airflow systems and even more with personnel-isolator systems.
Além do fluxo laminar de ar, qual outro processo também diminui a porcentagem de bactérias suspensas na sala cirúrgica?
Ultraviolet light also has been shown to decrease the incidence of wound infection by reducing the number of airborne bacteria; not recommended by the Hospital Infection Control Practice Advisory Committee.
Como reage o organismo do paciente ao procedimento cirurgico ortopédico em relação às bacterias?
During the first 24 hours, infection depends on the number of bacteria present. During the first 2 hours, the host defense mechanism works to decrease the overall number of bacteria. During the next 4 hours, the number of bacteria remains fairly constant, with the bacteria that are multiplying and the bacteria that are being killed by the host defenses being about equal. These first 6 hours are called the “golden period,” after which the bacteria multiply exponentially. The administration of prophy- lactic antibiotics expands the golden period.
Qual bacteria mais comum na pele?
S. aureus, although the frequency of Staphylococcus epidermidis is increasing.
Em relação a quimioprofilaxia, qual antibiotico deve ser administrado para o paciente alergico a penicilina? Qual antibiotico não deve ser usado de rotina?
Clindamycin can be given if a patient has a history of anaphylaxis to penicillin. Routine use of vancomycin for prophylaxis should be avoided.
Em que momento da cirurgia o antibiótico deve ser administrado? Quando deve ser repetido?
Ideally, antibiotic therapy should begin immediately before surgery (ideally 30 minutes before skin incision). Must be repeated every 4 hours intraoperatively or whenever the blood loss exceeds 1000 to 1500 mL.
Quanto tempo deve durar a quimioprofilaxia com antibióticos?
Prophylactic antibiotics should not be extended past 24 hours even if drains and catheters are still in place.
Comente sobre a colonização de MRSA entre cirurgiões e residentes.
Schwarzkopf et al. prospectively studied the prevalence of S. aureus colonization in orthopaedic surgeons and their patients and found that among surgeons and residents there was a higher prevalence of MRSA compared with a high-risk group of patients.
Qual é a tríade clássica da infecção?
he classic triad is fever, swelling, and tenderness (pain).
Durante um episódio de infecção aguda, qual porção do diferencial sanguineo aumenta?
The diferential shows increases in neutrophils during acute infections.
Em relação ao PCR e VHS, como eles se comportam durante um episódio de infecção aguda?
Peak elevation of the ESR occurs at 3 to 5 days after infection and returns to normal approximately 3 weeks after treatment is begun. CRP, synthesized by the liver in response to infection, is a better way to follow the response of infection to treatment. CRP increases within 6 hours of infection, reaches a peak elevation 2 days after infection, and returns to normal within 1 week ater adequate treatment has begun.
Na análise do aspirado articular, quais valores celulares sugerem infecção?
In septic arthritis, the cell count usually is greater than 80,000/mm3, with more than 75% of the cells being neutrophils.
No caso de uma biopsia por congelação, quais contagens de células brancas sugerem infecção?
Intraoperative frozen section also should be obtained in cases in which infection is suspected. A white blood cell count greater than 10 per high-power field is considered indicative of infection, whereas a count less than 5 per high-power field all but excludes infection.
Por que a avaliação radiológica não é um bom método para avaliar infeção aguda?
Bone destruction is not apparent on radiographs, however, until an infection has been present for 10 to 21 days. In addition, 30% to 50% of the bone matrix must be lost to show a lytic lesion on radiographs.
Como o processo infeccioso altera a imagem na TC?
CT can help determine the extent of medullary involvement. Pus within the medullary cavity replaces the marrow fat, causing an increased density on the CT scan. CT diagnosis of acute osteomyelitis is based on detection of intraosseous gas, osteolysis, sot tissue masses, abscesses, or foreign bodies.
Quais são os 3 radioisotopos mais utilizados nas cintilografias?
The three most commonly used radioisotopes are technetium, gallium and indium.
Como diferenciar uma celulite, osteomielite e um processo degenerativo pela cintilografia?
Cellulitis causes increased activity during the low and equilibrium phases and a decreased or normal uptake in the delayed phase. Osteomyelitis causes increased uptake in all three phases. Increased uptake in the delayed phase but not in the low or equilibrium phase suggests 99m degenerative joint disease.
Quais são os achados clássicos da osteomielite na RNM?
The classic findings of osteomyelitis on MRI are a decrease in the normally high marrow signal on T1 images and a normal or increased signal on T2 images. Although MRI is good for detailing marrow involvement and discitis, it does little to detect early cortical bone involvement.
Qual o momento ideal para se colher material para cultura?
Every efort should be made to obtain a culture specimen before antibiotic therapy is begun.
Quais os materiais preferidos para realizarem cultura?
The preferred specimen in most bacterial and yeast infections is aspirated fluid (joint or purulent luid). A deep wound biopsy or a curetted specimen ater cleaning the wound is acceptable. In certain bacterial and fungal infections, a tissue biopsy specimen from the edge of the wound is preferable. Aerobic and anaerobic swabs are more commonly used, but aspirated fluid or a tissue biopsy specimen is preferable.
O que é o MIC?
The lowest concentration of an antibiotic that inhibits growth of the patient’s isolate is designated the minimal inhibitory concentration (MIC).
O que é minimal bactericidal concentration?
The lowest concentration of antimicrobial agent that allows survival of less than 0.1% of the original cultured inoculum.
O que é serum bactericidal concentration (SBC)?
The lowest dilution of the patient’s serum that kills 99.9% of a standard inoculum is called the SBC.
Quais são os organismos mais comumente isolados? E nas proteses?
S. aureus is most frequently isolated in infectious arthritis. After this, N. gonorrhoeae is more common in adults younger than 30 years, and H. inluenzae type B is more common in children younger than 2 years. These three bacteria, along with various Streptococcus species, constitute most known isolates in joint infections. In contrast, prosthetic joint infections most often are caused by skin lora, such as S. epidermidis and other coagulase-negative Staphylococcus and gram-negative bacilli that are transient skin colonizers.
Qual organismo tem sua incidencia aumentando em osteomielite em neonatos e portadores de anemia falciforme?
S. aureus is the most frequent isolate in osteomyelitis, but Salmonella organisms have an increased incidence in patients with sickle cell anemia or neonatal osteomyelitis.
Qual a função do desbridamento na osteomielite?
Débridement reduces the inoculum and removes necrotic and avascular bone, bacteria, and harmful bacterial products.
Se um paciente não responder a antibioticoterapia entre 36 e 48h o que pode estar acontecendo?
If the patient does not respond to antibiotic treatment in 36 to 48 hours, the wrong antibiotic has been chosen or an abscess has formed.
Quais são os antibioticos geralmente associados ao cimento ósseo?
tobramycin, vancomycin, and gentamicin
Com o uso de tobramicina e vancomicina no cimento osseo, em que momento ocorre o pico de concentração desses antibioticos e quanto tempo esse pico ocorre?
With tobramycin and vancomycin, the peak concentration of antibiotic delivered to local tissue occurs on the first day and lasts for only approximately 1 week.
Quais efeitos o uso de quinolonas e tobramicina podem trazer ao organismo?
Quinolones have shown detrimental efects on chondrocytes and fracture healing; and tobramycin at intermediate levels of concentration (400 μg/mL) can decrease cell replication.
Quantas linhagens de HIV foram identificadas até hoje?
Two strains of HIV have been identified: HIV-1, which is the strain most common in the United States, and HIV-2, which has been reported primarily in Europeans, Africans, and rarely in the United States.
Qual célula humana o HIV parasita?
The HIV retrovirus is trophic for the CD4 surface receptors of T lymphocytes. The virus causes deregulation and destruction of these T lymphocytes, ultimately resulting in an immunodeicient state.
Quando ocorre a osteomielite?
Osteomyelitis occurs when an adequate number of a suficiently virulent organism overcomes the host’s natural defenses (inlammatory and immune responses) and establishes a focus of infection.
A partir de qual valor de CD4 as infecções oportunistas podem ocorrer?
When the CD4 cell count is less than 200/mm3 , opportunistic infections occur and clinical manifestations of AIDS begin.
Quais são as doenças oportunistas mais comuns nos pacientes com HIV?
P. jiroveci pneumonia and malignancies such as Kaposi sarcoma are the most common opportunistic diseases associated with AIDS in the United States.
Quais são os 4 estagios da infecção pelo HIV?
The stages are (1) acute primary HIV infection, (2) chronic asymptomatic HIV infection, (3) symptomatic HIV infection, and (4) advanced HIV-associated opportunistic disease or AIDS.
Quais são as manifestações musculoesqueleticas mais comuns nos pacientes com HIV?
The most common musculoskeletal syndromes in HIV-infected patients are manifestations of drug toxicity, reactive arthritis, infectious arthritis, myositis, tendinitis, and bursitis.
Quais são os principios gerais na avaliação de um paciente com HIV?
(1) Any musculoskeletal syndrome that occurs in non–HIV-infected patients can occur in HIV-infected patients; (2) HIV infection can alter the clinical presentation, severity, and course of musculoskeletal problems; and (3) early diagnosis of infections is especially important to prevent their spread in an immunocompromised patient.
Quais são os organismos mais isolados em artrite septica e bursite em pacientes com HIV?
Gram-positive bacteria, such as S. aureus and S. pneumoniae, commonly found in noninfected patients with septic arthritis and bursitis, also are the most frequently reported organisms causing septic arthritis and bursitis in HIV-infected individuals. Primary osteomyelitis has been reported in HIV-infected patients, but usually it is the result of direct extension from a septic joint.
Quais as possiveis causas de miosite nos pacientes com HIV?
Muscle pain or myositis is a common complaint in HIV- infected patients, including idiopathic polymyositis, poly-myositis secondary to zidovudine toxicity, and pyomyositis.
Quais são os 3 fatores que devem ser reconhecidos no risco de transmissão de HIV de um paciente para um cirurgião?
Three factors that must be known to calculate an orthopaedic surgeon’s risk of incurring HIV from punctures in the operating room are (1) the frequency of punctures, (2) the percentage of surgical patients who are HIV positive, and (3) the risk of HIV transmission per needle stick from known HIV-positive patients.
Quais a formas de transmissão de HIV são de grande risco?
Greatest risk for occupational transmission of HIV involved parenteral injection of blood through orthopaedic pins or hollow-core needles.
Quis são as chances de um ortopedista ser contaminado por HIV?
These figures put the annual risk to the orthopaedic surgeon between 0.025% and 0.5%, acumulative (>40 years of practice) risk of 0.6%.
O uso de duas luvas durante procedimentos diminui a chance de contato com sangue do paciente em qual porcentagem?
Double gloving reduces the risk of blood contact from 29% to 13%; however, the gloves must be changed at least every 2 hours or every hour for trauma cases.
O uso de quimioprofilaxia após o contato com sangue contaminado diminui em qual porcentagem o chance de soroconversão pelo HIV?
A decrease in seroconversion rates of 79% has been shown with the use of chemoprophylaxis ater exposure using zidovudine and lamivudine, chain terminators for reverse transcriptase. Adding a protease inhibitor, indinavir, further decreases antiretroviral activity. hese drugs should be started within 2 hours of exposure and generally are recommended for at least a 4-week course.
Qual a população mais acometida por osteomielite aguda hematológica?
Acute hematogenous osteomyelitis is more common in males in all age groups afected.
Como é a distribuição da osteomielite aguda hematogênica nas crianças?
The age distribution of acute hematogenous osteomyelitis in children is bimodal, generally afecting children younger than age 2 years and children aged 8 to 12 years. Half of all children with osteomyelitis are younger than 5 years of age.
Por que crianças menores que 2 anos estão susceptiveis a diminuição do membro e deformidade angular após osteomielite?
In children younger than 2 years, some blood vessels cross the physis and may allow the spread of infection into the epiphysis. For this reason, infants are susceptible to limb shortening or angular deformity if the physis or epiphysis is damaged from the infection. Otherwise, the physis acts as a barrier that prevents the direct spread of a metaphyseal abscess into the epiphysis.
Por que a região metafisária é mais susceptivel à osteomielite aguda na criança?
The metaphysis has relatively fewer phagocytic cells than the physis or diaphysis, allowing infection to occur more easily in this area.
Osteomielite na região diafisária ocorre com que frequencia?
The diaphysis rarely is involved, and extensive sequestration occurs infrequently except in the most severe cases.
Como funciona a fise na criança acima de 2 anos em relação a osteomielite aguda?
In children older than 2 years, the physis efectively acts as a barrier to the spread of a metaphyseal abscess. Because the metaphyseal cortex in older children is thicker, however, the diaphysis is at greater risk in these patients. If the infection spreads into the diaphysis, the endosteal blood supply may be jeopardized.
Em pacientes esqueleticamente maduros, qual o local mais comum de desenvolvimento de osteomielite hematologica aguda?
Although it can occur anywhere and in any part of the bone, generally the vertebral bodies are afected.
Como ocorre a pioartrite na criança abaixo de 2 anos? Qual é articulação mais acometida?
In children younger than 2 years, the common blood supply of the metaphysis and epiphysis crosses the physis and can allow spread of a metaphyseal abscess into the epiphysis and eventually into the joint. The hip joint is the most commonly afected in young patients; however, the physes of the proximal humerus, radial neck, and distal fibula also are intraarticular, and infection in these areas can lead to septic arthritis as well.
Qual patógeno é mais comum nas osteomielites em pacientes usuários de drogas injetáveis?
Pseudomonas is the most common infecting organism found in intravenous drug abusers with osteomyelitis.
Osteomielite fúngica é mais comum em qual tipo de paciente?
Fungal osteomyelitis is seen increasingly in chronically ill patients receiving longterm intravenous therapy or parenteral nutrition.
Qual patogeno é mais comum em pacientes com hemoglobinopatias?
Salmonella osteomyelitis has long been associated with SS or SC hemoglobinopathies. This infection tends to be diaphyseal rather than metaphyseal.
Qual é o patogeno mais comum em crianças saudáveis de 2 a 4 semanas de vida?
Group B Streptococcus is the most likely infecting organism found in otherwise healthy infants 2 to 4 weeks old.
Qual o patogeno mais comum nas osteomielites em crianças de 6 meses a 4 anos de idade?
Haemophilus influenzae infections occur primarily in children 6 months to 4 years old.
Quais doenças podem mimetizar osteomielite na radiografia? Qual exame pode ser utilizado para diferenciar?
Conditions that may be mistaken for osteomyelitis on plain radiographs include septic arthritis, Ewing sarcoma, osteosarcoma, juvenile arthritis, sickle cell crises, Gaucher disease, and stress fractures. Technetium 99m bone scans can conirm the diagnosis 24 to 48 hours after onset in 90% to 95% of patients; a negative technetiumbone scan efectively rules out the diagnosis of osteomyelitis.
Qual a aparência da osteomielite na RNM?
On T1-weighted MR images, osteomyelitis typically has low signal intensity; on T2-weighted and short-tau inversion recovery (STIR) images, it has a high marrow signal intensity.
Quais são os principios de Nade para o tratamento de osteomielite aguda hematogenica?
In 1983, Nade proposed five principles for the treatment of acute hematogenous osteomyelitis that are still applicable today: (1) an appropriate antibiotic is efective before abscess formation; (2) antibiotics do not sterilize avascular tissues or abscesses, and such areas require surgical removal; (3) if such removal is efective, antibiotics should prevent their reformation, and primary wound closure should be safe; (4) surgery should not damage further already ischemic bone and sot tissue; and (5) antibiotics should be continued ater surgery.
Quais são as duas indicações cirurgicas para a osteomielite aguda?
The two main indications for surgery in acute hematogenous osteomyelitis are (1) the presence of an abscess requiring drainage and (2) failure of the patient to improve despite appropriate intravenous antibiotic treatment.
Qual procedimento deve ser realizado na limpeza de um abscesso na criança?
When a subperiosteal abscess is found in an infant, several small holes should be drilled through the cortex into the medullary canal. If intramedullary pus is found, a small window of bone is removed.
Torniquete pode ser utilizado na limpeza de um abscesso?
Use a tourniquet whenever possible. Elevate the extremity for a few minutes before inlating the tourniquet. Do not exsanguinate the limb with an elastic bandage if infection is present.
Como deve ser imobilizada a tibia apos a drenagem de um abscesso?
A long-leg posterior plaster splint is applied with the foot in a neutral position, the ankle at 90 degrees, and the knee at 20 degrees of flexion.
Geralmente quanto tempo de antibiotico endovenoso é dado para uma criança com osteomielite aguda?
Generally, a 6-week course of intravenous antibiotics is given.
Qual porcentagem de pacientes com infecção primária desenvolvem osteomielite subaguda?
Subacute osteomyelitis is relatively common, reported to occur in over a third of patients with primary bone infections.
Como é a contagem da série branca nos pacientes com osteomielite subaguda?
White blood cell counts generally are normal. The erythrocyte sedimentation rate is elevated in only 50% of patients, and blood cultures usually are negative. Even with an adequate bone aspirate or biopsy specimen, a pathogen is identiied only 60% of the time. Plain radiographs and bone scans generally are positive
Como é a classificação de osteomielite subaguda de Gledhill e modificada por Roberts et al.?
Classification of subacute osteomyelitis: type 1, central metaphyseal lesion; type 2, eccentric metaphyseal lesion with cortical erosion; type 3, diaphyseal cortical lesion; type 4, diaphyseal lesion with periosteal new bone formation, but without deinite bony lesion; type 5, primary subacute epiphyseal osteomyelitis; and type 6, subacute osteomyelitis crossing physis to involve metaphysis and epiphysis.
Quais são os organismos predominatemente isolados nas osteomielites subagudas?
S. aureus and Staphylococcus epidermidis are the predominant organisms identified in subacute osteomyelitis.
Qual o tratamento geral para a osteomielite subaguda?
Biopsy and curettage followed by treatment with appropriate antibiotics generally are recommended for all lesions that seem to be aggressive: “biopsy all cultures and culture all biopsies.” For lesions that seem to be a simple abscess in the epiphysis or metaphysis, biopsy is not recommended. These lesions, which are characteristic of subacute hematogenous osteomyelitis, should be treated with intravenous antibiotics for 48 hours followed by a 6 week course of oral antibiotics.
O que é o abscesso de Brodie?
A Brodie abscess is a localized form of subacute osteomyelitis that occurs most oten in the long bones of the lower extremities of young adults.
Qual a queixa comum do paciente com abscesso de Brodie?
Intermittent pain of long duration is the presenting complaint, along with local tenderness over the afected area.
Qual a aparencia radiografica do abscesso de Brodie na radiografia?
On plain radiographs, a Brodie abscess generally appears as a lytic lesion with a rim of sclerotic bone, but it can have a markedly varied appearance.