Important x2 Flashcards
How do we group ascites
SAAG <11
SAAG >11
Causes of ascites
SAAG <11
Liver:
- liver cirrhosis
- acute liver failure
- liver mets
Cardiac:
- RHS heart failure
- constrictive pericarditis
Other:
- Budd-Chiari
- Myxoedema
Causes of ascites
SAAG >11
- nephrotic syndrome
- TB
- pancreatitis
Management of ascites
- reduce dietary sodium
- fluid restrict if Na+ <125
- bacterial prophylaxis: (PO cipro - note treatment for SBP is with IV ceftriaxone)
- Spiro
- Drainage (if more than 5L will require albumin as well)
Warfarin
- major bleed
Stop warfarin
IV vitamin K 5mg
Prothrombin complex
Warfarin
- INR >8.0
- minor bleed
Stop warfarin
Give IV vitamin K 1-3mg
Repeat INR if remains high to repeat vitamin K dose
Restart warfarin when INR < 5.0
Warfarin
- INR >8.0
- no bleeding
Stop warfarin
Given IV vitamin K 5 mg in oral form
Repeat in 24 hours if INR not less than 5.0
Repeat INR and restart once INR < 5.0
Warfarin 5.0-8.0
- Minor bleeding
Stop warfarin
Give intravenous vitamin K 1-3mg
Restart when INR < 5.0
Warfarin 5.0-8.0
- no bleeding
Withhold 1 or 2 doses of warfarin
Reduce subsequent maintenance dose
When to add oral cipro for ascites
People with cirrhosis and ascites with an ascitic protein of 15 g/litre or less, until the ascites has resolved
What do you need to rule out in acute UC
CMV
Diagnostic indicator for SBP
neutrophils >250
SBP treatment and prophylaxis
Treatment: Oral cefotaxime
Prophylaxis: Oral cipro
K+ replacement
1mmol/kg/day
Type 1 renal tubular acidosis
low K+, renal stones
Type 2 renal tubular acidosis
low K+, osteomalacia
Type 3 renal tubular acidosis
low K+
Type 4 renal tubular acidosis
high K+
Tumour lysis syndrome electrolytes
Low Ca2+, high PO43-, high K+
Tumour lysis management
Rasburicase (uric acid to allutonin)
Prevention of haemorrhagic cystitis
Mesna
Sideroblastic anaemia management
Pyridoxine
Acute promyelotic leukaemia
DIC t(15;17)
Hodgkins chemo
ABVD
Non hodgkins chemo
RCHOP
TIA management
Aspirin 300mg then aspirin 75mg for 2 weeks and then switch to clopidogrel 75mg
note if already on an anticoagulant continue this
Brown-Sequard sx
- Ipsilateral motor loss
- Contralateral temperature and pain and vibration loss
Multiple system atrophy symptoms
Parkinsons + cerebellar + postural hypotension
PSP
Parkinsons + downward vision
Miller Fisher Syndrome
Like GBS but affects the eyes
GQ1b antibodies
PCA stroke
CN III palsy, ipsilateral (down and out)
PICA stroke
ipsilateral facial pain and temp. loss, nystagmus and ataxia
AICA stroke
Like PICA but also has facial paralysis and deafness
Chlamydia antibiotics
PO doxy for 7 days (azithromycin if pregnant)
Toxoplasmosis treatment
Sulfadazine and pyrimethiadone
Falciparum malaria mx
artenusate
Non-falciparum mx
quinine and doxy (need to check for G6PD deficiency)
Rabies histology
Negri bodies
Prostaglandin analogues
end in -prost
Endothelin antagonists
end in -tan
Clari moa
Inhibits ribosome 50s subunit
Hep A cause
Seafood (hep E is pork)
Herpes in question with pneumonia
Pneumococcal pneumonia
Malaria with high parasitic count
Plasmodium Knowles
Cyclical fevers with malaria
- 48 hours
- 72 hours
48: plasmodium vivax
72: plasmodium malariae
Diptheria management
IM penicillin
Cat scratch cause
Bartonella
Dog scratch cause
Pasturella mucocida
Pleural effusion transudate
<30g/L
Transudate causes
Heart failure
Hypoalbuminaemia e.g. nephrotic
Liver disease
Meigs
Hypothyroid
Meigs
Ovarian cancer +pleural effusion +ascites
Pleural effusion exudate
> 30g/L
Pleural effusion exudate causes
Infection - pneumonia, TB
RA, SLE
Malignancy
Pleural effusion ix
PA chest XR, US, CT if exudative cause
Pleural effusion should be sent for
pH, protein, lactate dehydrogenase (LDH), cytology and microbiology
Lights criteria
Protein level is between 25-35 g/L
An exudate is likely if at least one of the following criteria are met:
pleural fluid protein divided by serum protein >0.5
pleural fluid LDH divided by serum LDH >0.6
pleural fluid LDH more than two-thirds the upper limits of normal serum LDH
When to insert a chest drain for pleural effusion
If septic, empyema, cloudy fluid
If clear, pH less than 7.2 then chest drain should be inserted
MEN I
Parathyroid gland: hyperparathyroidism
Pancreatic: pancreatic neuroendocrine tumour
Women: breast cancer
MEN 2a
95% of patients with MEN 2 have MEN 2a
- medullary thyroid cancer
- phaeochromocytoma
- hyperparathyroidism
MEN 2b
- medullary thyroid cancer
- phaeochromocytoma
- mucosal neuroma
- skeletal abnormalities
- Sjogrens
MEN 1 gene mutation
MEN 1
MEN 2 gene mutation
RET