Immunosuppresants

Question 1

Cyclosprine and Tacrolimus use and MOA

Answer 1

Both inhibit calcineurin to block T cell acrivation (block IL-2)

cyclosporine - binds to cyclophilin

Tacrolimus - binds to FK506

Question 2

Sirolimus MOA

Answer 2

mTOR inhibitor - stops the proliferation of genes (especially IL-2)

Question 3

Methotrexate MOA

Answer 3

Mimics folic acid, inhibits dihydrophoate reductase

Stops ability to make dTMP and DNA

Question 4

Mycophenolate MOA

Answer 4

Inhibits IMP dehydrogenase, use in purine synthesis in lymphocytes

Question 5

Cyclophosphamide MOA

Answer 5

Adds alkyl group to DNA that causes crosslinking and damage, inhibits DNA replication

Question 6

Azathioprine MOA

Answer 6

Converted to 6-mercaptopurine

Analog of hypoxanthine (purine), competes to binding of HGPRT, so blocks purine salvage pathway

Question 7

Drug interaction with azothioprine

Answer 7

Allopurional - a xanthine oxidase inhibitor

Blocks metabolism of 6-MP

Question 8

Infliximab MOA

Answer 8

Chimeric MAB against TNF-alpha

For RA, crohns