Immunology: Week I Immunology I quiz Qs Flashcards

1
Q

19 year old male presents to A&E with severe respiratory difficulty, light-headedness and a red itchy rash. On examination he has laryngeal oedema, bilateral wheezing across the lung fields and is hypotensive. He has recently been taking antibiotics for a chest infection. Most likely diagnosis?

A. Allergic Rhinitis

B. Allergic bronchopulmonary Aspergillosis

C. Allergic asthma

D. Anaphylaxis

E. Angioedema

A

D. Anaphylaxis

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A. Allergic Rhinitis

B. Allergic bronchopulmonary Aspergillosis

C. Chronic Urticaria

D. Allergic asthma

E. Contact dermatitis

F. Drug allergy

G. Food allergy

H. Anaphylaxis

I. Acute Urticaria

J. Angioedema

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2
Q

A 25 year old woman presents to her GP complaining of itchy, red wheals on her torso which have been present for 7 weeks. She can not remember how they started but has noticed they are worse in the heat and when she exercises. Most likely diagnosis?

A. Chronic Urticaria

B. Contact dermatitis

C. Drug allergy

D. Acute Urticaria

E. Angioedema

A

D. Acute Urticaria

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3
Q

A 55 year old man with history of angina was advised to take a tablet before a long flight. After taking the pill, he suddenly finds that he has difficulty breathing, feels nauseous and is itching. Most Likely diagnsosis?

A. Mast cell degranulation

B. Extrinsic allergic alveolitis

C. Urticarial vasculitis

D. Idiopathic angioedema

E. Allergic asthma

A

A. Mast cell degranulation

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A. Chronic urticaria

B. Panic attack

C. Coeliac disease

D. C1 inhibitor deficiency

E. Mast cell degranulation

F. Extrinsic allergic alveolitis

G. IgE mediated anaphylaxis

H. Urticarial vasculitis

I. Idiopathic angioedema

J. Acute urticaria

K. Allergic asthma

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4
Q

A 24 year old medical student develops worsening swelling of the hands and feet and abdominal pain before her final year medical exams. She says that similar milder episodes have occurred preciously. Most likely diagnosis?

A. Panic attack

B. Coeliac disease

C. C1 inhibitor deficiency

D. IgE mediated anaphylaxis

E. Idiopathic angioedema

A

C. C1 inhibitor deficiency

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5
Q

A 35 year old woman presents with a two day history of a red itchy skin rash which started soon after her first scuba-diving lesson. She is otherwise well. Most likely diagnosis?

A. Allergic conjunctivitis

B. Contact hypersensitivity

C. Hereditary angioedema

D. Acute angioedema

E. Acute urticaria

A

E. Acute urticaria

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A. Allergic conjunctivitis

B. Contact hypersensitivity

C. Allergic rhinitis

D. Allergic bronchopulmonary aspergillosis

E. Allergic asthma

F. Hereditary angioedema

G. Chronic urticaria

H. Acute angioedema

I. Acute urticaria

J. Anaphylaxis

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6
Q

A 22 year old woman presents with an intermittently itchy and desquamating skin rash on her abdomen which is unresponsive to antihistamines. Most likely diagnosis?

A. Contact hypersensitivity

B. Allergic bronchopulmonary aspergillosis

C. Hereditary angioedema

D. Chronic urticaria

E. Acute angioedema

A

A. Contact hypersensitivity

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7
Q

This 45 year old woman presents to A&E with tongue swelling and acute respiratory tract obstruction. She has longstanding hypertension and received a renal transplant two years previously. She has no history of allergic disease. On examination her blood pressure is stable, and examination of her lung fields reveal normal breath sounds. Her current medication includes cyclosporine, azathioprine, captopril and nifedipine. Most likely diagnosis?

A. Allergic rhinitis

B. Allergic bronchopulmonary aspergillosis

C. Allergic asthma

D. Hereditary angioedema

E. Acute angioedema

A

E. Acute angioedema

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A. Allergic conjunctivitis

B. Contact hypersensitivity

C. Allergic rhinitis

D. Allergic bronchopulmonary aspergillosis

E. Allergic asthma

F. Hereditary angioedema

G. Chronic urticaria

H. Acute angioedema

I. Acute urticaria

J. Anaphylaxis

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8
Q

A 40 year old man complains of loss of smell with nasal itching and discharge over 4 weeks. He also describes morning sneezing. He is otherwise in good health. On examination his nasal mucosa are swollen and hyperaemic. What is the best option for management?

A. IM adrenaline 1mL of 1:1000

B. IM adrenaline 0.5 mL of 1:1000

C. Inhaled corticosteroids

D. PO antihistamines

E. Intranasal antihistamines

A

D. PO antihistamines

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A. Venom immunotherapy

B. IV adrenaline 0.3mL of 1:1000

C. IM adrenaline 1mL of 1:1000

D. Intracardiac adrenaline

E. IM adrenaline 0.5 mL of 1:1000

F. Inhaled antihistamines

G. Intraarticular corticosteroids

H. IV antihistamines

I. Inhaled corticosteroids

J. PO antihistamines

K. Intranasal antihistamines

L. None of the above

M. IM adrenaline 1mL of 1:10000

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9
Q

This 45 year old woman presents to A&E with tongue swelling and acute respiratory tract obstruction. She has longstanding hypertension and received a renal transplant two years previously. She has no history of allergic disease. On examination her blood pressure is stable, and examination of her lung fields reveal normal breath sounds. Her current medication includes cyclosporine, azathioprine, captopril and nifedipine. What is the best option for management?

A. IV adrenaline 0.3mL of 1:1000

B. IM adrenaline 1mL of 1:1000

C. Intracardiac adrenaline

D. IM adrenaline 0.5 mL of 1:1000

E. Inhaled corticosteroids

A

D. IM adrenaline 0.5 mL of 1:1000

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10
Q

Immunoglobulin dimer:

A. IgA

B. Interferons

C. IgG

D. IgM

E. IgE

A

A. IgA

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A. Innate immune system

B. CD8+

C. IgA

D. Alternative complement pathway

E. IL6

F. Interferons

G. IgG

H. IgM

I. Major histocompatability complex class 2

J. Classical complement pathway

K. Major histocompatability complex class 1

L. IgE

M. Natural Killer cells

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11
Q

Arise in the first few days after infection and are important in defence against viruses and tumors.

A. IL6

B. Interferons

C. IgG

D. IgE

E. Natural Killer cells

A

E. Natural Killer cells

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12
Q

Deficiencies in this predispose to SLE

A

Classical complement pathway

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13
Q
A
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14
Q

Along with IgD, is one of the first immunoglobulins expressed on B cells before they undergo antibody class switching?

A

IgM

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15
Q

MHC associated with Th2 cells

A

Major histocompatability complex class 2

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Th1 and Th2 cells?

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16
Q

Kostmanns syndrome is a congenital deficiency of which component of the immune system?

A

Neutrophils

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“Good nutrition costs alot man”

17
Q

Which type of infection is most common as a consequence of B cell deficiency?

A

Fungal

18
Q

Meningococcal infections are quite common as a result of which deficiency of the component of the immune system?

A

Complement

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Complimeng

19
Q

A complete deficiency in this molecule is associated with recurrent respiratory and gastrointestinal infections

A

IgA

20
Q

Which crucial enzyme is vital for the oxidative killing of intracellular micro-organisms?

A

NADPH oxidase

21
Q

What is the functional complement test used to investigate the classical pathway?

A

CH50

22
Q

Type 1 diabetes. What type of autoimmune hypersensitivity reaction?

A

Type IV – T-cell mediated