Chemical Pathology: Liver disease CPC Flashcards
Causes of raised Bilirubin?
- Haemolytic Anaemia (Haemolysis)
- Gilberts disease
- Liver cirrhosis
- Cholangitis
- Hepatitis
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Pre-hepatic (eg haemolysis)
Hepatic (Repeat LFTS)
Post hepatic (Obstructive jaundice)
Raised ungongugated bilirubin suggests?
Liver problem, since liver congugates Bilirubin.
How do you differentiate between obstructive and non-obstructive causes of jaundice?
Urine uribinogen.
uribinogen in urine suggests non-obstructive cause of raised bilirubin.
No uribinogen suggests obstructice cause of raised bilirubin.
In the context of jaundice, what does raised AST and raised ALT suggest?
Hepatic cause of jaundice
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Raised AST and raised ALT indicate liver damage
In the context of jaundice, what does a raised Alk Phos suggest?
Obstructive cause of jaundice (eg gallstones)
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Not sure why really
Spider Naevi
Gynocomastea
Palmer erythema
Dupuytrens contracture
Most likely diagnosis?
Alcoholic hepatitis
Signs of Portal hypertension?
Splenomegaly
Visible veins
Ascites (Shifting dullness)
Patient is jaundiced and the gallbladder is palpable. What is the most likely diagnosis?
Pancreatic cancer
Two causes of obstructive jaundice?
Gallstones
Pancreatic cancer
