Immunology Of Joint Conditions Flashcards
Does the innate or adaptive immune system distinguish between pathogens
Adaptive
What does the innate immune system recognise on pathogens
PAMPs pathogen associated molecular patterns
Cells involved in innate immunity
NK cells
Granulocytes inc neutrophil
Monocytes and macrophages
Dendritic cells
Cells involved in adaptive immunity
T cells
B cells + antibodies
Antigen presenting cells
Is the light chain or heavy chain on an antibody variable
Light chain
Heavy chain constant
How can the adaptive immune system create infinite types of specific antibodies
Different combinations of v(variable), j (joining), and d (diversity)chains
What process prevents auto reactive immune cells being made
Immunological tolerance
Immunological tolerance
process by which immune cells are made unresponsive to self-antigens by prior exposure and self reactive cells are killed
2 types of immunological tolerance
Central tolerance - thymus+bone marrow
Peripheral tolerance
What type of immune molecular are leukotrienes, PAF, and PH
G
Lipid mediators
What type of immune molecule are IL1, IL6, IL8, IL12, and TNFalpha
Cytokines
What kind of immune molecule are IL8, MCP1, and fractalkine
Chemokines
What type of immune molecule are C2a, C3a, and C5a
Complement
Process of inflammation
Pathogen triggers macrophages to release cytokines and chemokines ->
Vasodilation and incr vascular permeability ->
Heat redness and swelling ->
Inflam cells migrate to tissue and release inflam mediators ->
Pain
What does continued immune cell activation lead to
Chronic inflammation
Protease production -> destroy tissue
