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Year 3 Exams: Endocrine > Immunology in Endocrine > Flashcards

Immunology in Endocrine Flashcards

1
Q

What is important in B Cell Tolerance?

A

Bone Marrow

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2
Q

Peripheral tolerance is maintained by?

A

T Regs that suppress lymphocyte activation

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3
Q

Which autoimmune disease is not more common in females?

A

Ankylosing Spondylitis

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4
Q

Ankylosing Spondylitis gene?

A

B27 HLA

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5
Q

Addisons, Hashimoto and myasthenia Gravis gene?

A

DR3 HLA

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6
Q

Insulin does what to Lipolysis?

A

Inhibits

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7
Q

Beta cells produce

A

Insulin

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8
Q

Alpha cells produce

A

glucagon

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9
Q

Glycogen is broken down in?

A

Liver

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10
Q

Delta cells produce

A

Somatostatin

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11
Q

Type 1 Diabetes: which viruses predispose?

A

Coxsackie B and Mumps

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12
Q

Thyroid Gland synthesises?

A

T3 and T4 under negative feedback

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13
Q

Most common cause of Thyrotoxicosis

A

Graves Disease

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14
Q

Presentation of Graves Disease (3)

A

Pretibial Myxoedema
Finger Clubbing
Exopthalamos

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15
Q

Pretibial Myoxoedema is caused by?

A

Accumulation of Mucopolysaccharides

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16
Q

When hypothyrodism is congenital it causes?

A

Cretinism

17
Q

Most common cause of Hypothyroid?

A

Hashimoto

18
Q

What happens to metabolic rate in Hypothyroid?

A

Decrease

19
Q

What cells are present in Hashimoto?

A

Akanazy Cells and Hurthle Cells

20
Q

Autoimmune Polyendocrine Syndrome Type 1 Presents with? (2)

A

Chronic Mucocutaneous Candiasis

Hypoparathyroid

21
Q

Autoimmune Polyendocrine Syndrome Type 1 mutations in what gene?

A

AIRE Gene

22
Q

Primary Adrenal Insufficiency (Addisons) can cause what repro issue?

A

Primary Ovary Insufficiency

23
Q

Autoimmune Polyendocrine Syndrome can get what 3 Complications?

A

Coeliac
Primary Ovary Insufficiency
Pernicious Anaemia

24
Q

What does HBA1C Monitor?

A

Glucose not taken into cells due to lack of insulin

25
Q

HBA1c is said to be what within Red Blood Cells?

A

Intracellular

26
Q

Glucose moves freely into what type of cell?

A

Red blood cell

27
Q

What drug can be used for Obesity?

A

Orlistat

Year 3 Exams: Endocrine (34 decks)

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