Immunology in Endocrine Flashcards
What is important in B Cell Tolerance?
Bone Marrow
Peripheral tolerance is maintained by?
T Regs that suppress lymphocyte activation
Which autoimmune disease is not more common in females?
Ankylosing Spondylitis
Ankylosing Spondylitis gene?
B27 HLA
Addisons, Hashimoto and myasthenia Gravis gene?
DR3 HLA
Insulin does what to Lipolysis?
Inhibits
Beta cells produce
Insulin
Alpha cells produce
glucagon
Glycogen is broken down in?
Liver
Delta cells produce
Somatostatin
Type 1 Diabetes: which viruses predispose?
Coxsackie B and Mumps
Thyroid Gland synthesises?
T3 and T4 under negative feedback
Most common cause of Thyrotoxicosis
Graves Disease
Presentation of Graves Disease (3)
Pretibial Myxoedema
Finger Clubbing
Exopthalamos
Pretibial Myoxoedema is caused by?
Accumulation of Mucopolysaccharides
When hypothyrodism is congenital it causes?
Cretinism
Most common cause of Hypothyroid?
Hashimoto
What happens to metabolic rate in Hypothyroid?
Decrease
What cells are present in Hashimoto?
Akanazy Cells and Hurthle Cells
Autoimmune Polyendocrine Syndrome Type 1 Presents with? (2)
Chronic Mucocutaneous Candiasis
Hypoparathyroid
Autoimmune Polyendocrine Syndrome Type 1 mutations in what gene?
AIRE Gene
Primary Adrenal Insufficiency (Addisons) can cause what repro issue?
Primary Ovary Insufficiency
Autoimmune Polyendocrine Syndrome can get what 3 Complications?
Coeliac
Primary Ovary Insufficiency
Pernicious Anaemia
What does HBA1C Monitor?
Glucose not taken into cells due to lack of insulin
HBA1c is said to be what within Red Blood Cells?
Intracellular
Glucose moves freely into what type of cell?
Red blood cell
What drug can be used for Obesity?
Orlistat
