Adrenal Disorders Flashcards
Name a Mineralcorticoid?
Aldosterone
Name a Glucocorticoid?
Cortisol
Name two hormones produced by Medulla?
Epinephrine and Norepinephrine
Addisons Disease is it hypo or hyper secretion of Cortisol?
Hyposection
What happen to autoantibodies in Addisons?
Posterior Adrenal Autoantibodies to 21 Ohase
Which part of the Adrenal Gland is affected in Addisons?
Cortex
What three conditions are associated with Addisons?
Ovarian Failure
Thyroid Disease
Type 1 Diabetes
What happens to blood pressure in Addisons?
Hypotension
Unexplained Hypoglycemia happens in what Endocrine conditions?
Addisons Disease
What happens to periods in Addisons?
Amenorrhoea
How to Diagnose Addisons? (3)
Random Cortisol <50
Synacthen and Basal ACTH <450
Raised Plasma ACTH
What should random cortisol be below in Addisons?
50
What should Synacthen and Basal ACTH be below in Addisons?
<450
What three steroids to treat Addisons?
Hydrocortisone
Prednisolone
Dexamethasone
What treatment to use to replace mineralocorticoid in Addisons?
Fludocortisone
What is Fludocortisone’s actions in Addisons?
Binds to Aldosterone Receptors
Fludocortisone dose in Addisons should be adjusted according to? (4)
Plasma Renin
Postural BP
Oedema
U+E
When should special care be taken in Addisons?
Suppressed pituitary adrenal axis >7.5mg Prednisolone
Treatment during previous 18/12
Short Lived Illness
Major Illness
How much prednisolone is enough to suppress pituitary adrenal axis?
> 7.5mg
How to treat short lived illness in Addisons?
Glucorticoid x2
How to treat major illness in Addisons?
Hydrocortisone
