Cranial Diabetes Insipidius

Question 1

Main feature of Diabetes Insipidius?

Answer 1

> 3 Litres of Dilute Urine a Day

Question 2

How does Diabetes Insipidius happen?

Answer 2

Decreased ADH Secretion from Posterior Pituitary or Response to ADH

Question 3

Causes of Diabetes Insipidius Cranial?

Answer 3

Head injury
Tumour
Meningitis
Surgery
Radiotherapy
Idiopathic

Question 4

Causes of Nephrogenic Diabetes Insipidius? (5)

Answer 4

CKD
AVPR2 Gene on X chromosome which codes for ADH Receptor
Hypoclcaemia
Hypokalaemia
Lithium

Question 5

Diagnosis of Diabetes Insipidius? (3)

Answer 5

Decreased Kidney Osmolarity
24 Hour Urine Volume >50ml
Water Deprivation Test to Desmopressin

Question 6

How to Treat Diabetes Insipidius? (1)

Answer 6

Desmopressin

Question 7

Where does ADH act on kidneys?

Answer 7

Collecting ducts to allow them to reabsorb water from jurine

Question 8

Symptoms of Diabetes Insipidius?

Answer 8

Polyuria and Polydipsia

Question 9

How to distinguish Cranial from Nephrogenic Diabetes Insipidius in Water Deprivation test?

Answer 9

Cranial DI: Decreased After Depression and Increased after ADH
Nephrogenic: Decreased for both