Acromegaly Flashcards
1
Q
Which hormones are involved in Acromegaly?
A
Increased Secretion of Growth Hormone (Somatotropin)
2
Q
Somatotropin is released from?
A
Anterior Pituitary
3
Q
GHRH is released from?
A
Hypothalamus
4
Q
What inhibits GHRH and Stimulates Somatostatin Release?
A
IGF-1 and Growth Hormone Release
5
Q
Symptoms of Acromegaly? (9)
A
Weight Gain Macrogathia Frontal Bossing Bitemporal Hemianopia Protruding Jaw Spade like Fingers Amenorrhoea Coarse Facial Features Big Hands/Feet
6
Q
Which MSK condition is associated with Acromegaly? (1)
A
Carpal Tunnel Syndrome
7
Q
Diagnosis of Acromegaly?
A
Increased IGF1
MRI
Oral Glucose Tolerance
8
Q
What hormone is suppressed in Oral Glucose Tolerance for Acromegaly?
A
Growth Hormone
9
Q
How to Treat Acromegaly? (3)
A
Remove Tumour Somatostatin Analogue eg IM Sandostatin GH Inhibition (Pegvisomant)
10
Q
Adverse effects to Somatostatin Analogues in Acromegaly? (3)
A
Cholesterol Gallstones
Gallbladder Disease
Bradycardia
11
Q
Complications of Acromegaly? (6)
A
Chiasma Compression Colonic Polyps Diabetes Cardiomyopathy Sleep Apnoea Accelerated Osteoarthritis
