Immunology- Immunotherapy Flashcards
Which type of conditions can immunotherapy be used for?
Allergy
Autoimmuinity
Which type of cell produce cytokines?
T cells
What is active immunity like in terms of specificity and memory?
Has both memory and specificity
What is passive immunity like in terms of specificity and memory?
Has specificity but no memory
Give some examples of situations where passive immunity would be used.
Snake or spider bites, scorpion or fish stings
- passive infusion of antibody specific for the toxin
Rabies vaccination with the immunoglobulin
(Rabies is a viral agent introduced into subcutaneous tissue that is transported to the brain and spinal cord after attachment to peripheral nerve axons. However, the virus has a phase of slow replication and persistence in subcutaneous tissues during which prevention of attachment to neurons by antibody is possible),
List some of the conditions that Human Normal Immunoglobulin (HNIG) is used as post-exposure prophylaxis.
Hepatitis A
Measles
Polio
Rubella
List some of the conditions that specific immunoglobulins are required as post-exposure prophylaxis.
Hepatitis B
Rabies
Tetanus
Varicella-Zoster Virus
What is IVIg?
Plasma-derived IgG is used replacement therapy in primary and secondary immunodeficiency disorders and some autoimmune disorders
IVIg is the IV preparation
What are the two types of immunotherapy?
Direct
Indirect
Where is the target for direct immunotherapy?
Tumour
->direct immunotherapy are identifying an antigen present on the tumour
Where is the target for indirect immunotherapy?
Immune system
->immune system is activated to seek and steory the tumour cells
Give examples of types of direct immunotherapies.
Monoclonal antibodies
Chimeric antigen receptors
(CARs)
Bi-specific antibodies
Give some examples of indirect immunotherapies.
Tumour vaccines
Dendritic cell vaccines
Adoptive cell transfer
Cytokine therapies
Checkpoint inhibitor therapies
Stimulatory antibodies
What are cytokine therapies used for?
Activate anti-tumour immunity
Used in specific cancers
In which condition is rituximab, a type of monoclonal antibody immunotherapy, the first line treatment?
Non-Hodgkin’s lymphoma
What is Infliximab, a type of anti-TNF immunotherapy, used in the treatment of?
Rheumatoid arthritis
Ankylosing spondylitis
Crohn’s disease
Ulcerative colitis
