Immunology- Autoimmunity

Question 1

Autoimmuinity?

Answer 1

Immune response against a self-antigen(s)

Question 2

Autoimmune disease?

Answer 2

Tissue damage or disturbed physiological function due to an autoimmune response

Question 3

What are the two categories of autoimmune disease?

Answer 3

Organ specific
Non-organ specific

Question 4

Hyper/hypothyroidism are autoimmune conditions against which self-antigen?

Answer 4

TSH receptor

Question 5

Hyper/hypoglycaemia are autoimmune conditions against which self-antigen?

Answer 5

Insulin receptor

Question 6

Myasthenia gravis is an autoimmune condition against which self-antigen?

Answer 6

Acetylcholine receptor

Question 7

Acquired haemophilia is an autoimmune condition against which self-antigen?

Answer 7

Factor VIII

Question 8

Antiphospholipid syndrome is an autoimmune condition against which self-antigen?

Answer 8

Beta-2 glycoproteins and other anticoagulant proteins

Question 9

Haemolytic anaemia is an autoimmune condition against which self-antigen?

Answer 9

RBCs

Question 10

Thrombocytopenic purpura is an autoimmune condition against which self-antigen?

Answer 10

Platelets

Question 11

Are autoimmune conditions more common in women or men?

Answer 11

Women

->only exception is ankylosing spondylitis

Question 12

What can immune related medications cause commonly as side effects?

Answer 12

Inflammation

Question 13

What are some of the contributing factors to autoimmune disease which break down tolerance?

Answer 13

Genes
Environment
Infection

Question 14

Which HLA gene is associated with ankylosing spondylitis?

Answer 14

HLA B27

Question 15

Which HLA gene is associated with Goodpasture syndrome?

Answer 15

HLA DR2

Question 16

Which HLA gene is associated with Addison’s disease, Hashimoto thyroiditis, myasthenia gravis?

Answer 16

HLA DR3

Question 17

Which HLA gene is associated with insulin-dependant diabetes mellitus?

Answer 17

HLA DR4

Question 18

Which environmental factor can trigger SLE skin lesions?

Answer 18

UV exposure

Question 19

Smoking increases risks of which autoimmune conditions?

Answer 19

Rheumatoid arthritis
Hashimoto’s
Grave’s disease

Question 20

What is more sensitive for the diagnosis of rheumatoid arthritis rather than rheumatoid factor?

Answer 20

Anti-CCP antibodies