Immunology- Autoimmunity Flashcards
Autoimmuinity?
Immune response against a self-antigen(s)
Autoimmune disease?
Tissue damage or disturbed physiological function due to an autoimmune response
What are the two categories of autoimmune disease?
Organ specific
Non-organ specific
Hyper/hypothyroidism are autoimmune conditions against which self-antigen?
TSH receptor
Hyper/hypoglycaemia are autoimmune conditions against which self-antigen?
Insulin receptor
Myasthenia gravis is an autoimmune condition against which self-antigen?
Acetylcholine receptor
Acquired haemophilia is an autoimmune condition against which self-antigen?
Factor VIII
Antiphospholipid syndrome is an autoimmune condition against which self-antigen?
Beta-2 glycoproteins and other anticoagulant proteins
Haemolytic anaemia is an autoimmune condition against which self-antigen?
RBCs
Thrombocytopenic purpura is an autoimmune condition against which self-antigen?
Platelets
Are autoimmune conditions more common in women or men?
Women
->only exception is ankylosing spondylitis
What can immune related medications cause commonly as side effects?
Inflammation
What are some of the contributing factors to autoimmune disease which break down tolerance?
Genes
Environment
Infection
Which HLA gene is associated with ankylosing spondylitis?
HLA B27
Which HLA gene is associated with Goodpasture syndrome?
HLA DR2
Which HLA gene is associated with Addison’s disease, Hashimoto thyroiditis, myasthenia gravis?
HLA DR3
Which HLA gene is associated with insulin-dependant diabetes mellitus?
HLA DR4
Which environmental factor can trigger SLE skin lesions?
UV exposure
Smoking increases risks of which autoimmune conditions?
Rheumatoid arthritis
Hashimoto’s
Grave’s disease
What is more sensitive for the diagnosis of rheumatoid arthritis rather than rheumatoid factor?
Anti-CCP antibodies
