Immunology and Allergology

Question 1

T-cells are detected in the thymus on what week of gestation

Answer 1

7th-8th

Question 2

Mucosa associated lympoid tissues

Answer 2

Pe-L-T (Peyer’s patches, lymphoid follicles, tonsils, submucosal lymphoid tissue)

Question 3

A protein released by Natural Killer Cells that creats pores on cell membranes of target cells resulting in lysis

Answer 3

Cytolysin

Question 4

1st line of defense vs neonatal herpes infection

Answer 4

NKC

Question 5

This Activates and influences production of eosinophils

Answer 5

IL-5

Question 6

Largest immunoglobulin

Answer 6

IgM

Question 7

Most abundant Ig, only Ig that can traverse the placenta

Answer 7

IgG

Question 8

Ig predominantly found on the human B lymphocytes

Answer 8

IgD

Question 9

Basis of tissue compatibilty in recipient donor screening

Answer 9

Human leukocyte antigens

Question 10

Immunopathologic Rxn in: asthma, urticaria, allergic rhinitis, anaphylaxis

Answer 10

Type I ( immediate hypersensitivity)

Question 11

Immunopathologic Rxn in: hemolytic disease, erythroblastosis fetalis, gradt rejection, chronic keratitis, goodpastures, blood transfusion, ITP

Answer 11

Type II (cytotoxic rxn)

Question 12

Immunopathologic Rxn in: PSGN, serum sickness, RA, SLE, Steven Johnson syndrome, polyarteritis nodosa

Answer 12

Type III (Immune Complex Mediatied)

Question 13

Immunopathologic Rxn in: PPD test, contact allergic dermatitis , syphilis. Leprosy

Answer 13

Type IV(Delayed type)

Question 14

Bruton’s disease

Answer 14

X-linked agammaglobulinemia

Question 15

Block in the development of preB to B cell due to a defect in heavy chain gene rearrangement

Answer 15

X-linked agammaglobinemia

Question 16

Management for Burton’s disease

Answer 16

Gamma globulin IM once a month at interval of 2-3 weeks

Question 17

Aberrant thymus or absence of(occuring at 12th week of gestation)

Answer 17

DiGeorge syndrome/ congenital thymic aplasia

Question 18

Management for DiGeorge

Answer 18

Fetal thymus transplant

Question 19

Other abnormalities associated with DiGeorge

Answer 19

Catch 22 ( cardiac abnorm, abnormal facies, thymic hypoplasia, cleft palate, hypocalcemia)

Question 20

Selective defect in cell-mediated immunity with susceptibility to chronic candida infection of the skin and mucous membranes w/ or w/o endocrinopathy

Answer 20

Sever combined immunodeficiency disorder

Question 21

Deficiency of tyrosine kinase that blocks B cell maturation

Answer 21

Bruton’s x-linked agammo

Question 22

Deficiency of CD40L on activated T cell

Answer 22

X linked hyper IgM syndrome

Question 23

Deficiency of IgA (most common)

Answer 23

Selective IgA deficiency

Question 24

Delayed onset of maturation of normal IgG

Answer 24

Transient Agammaglobulinemia

Question 25

Thymic hypoplasia

Answer 25

DiGeorge syndrome

Question 26

Defect in cystoskeletal glycoprotein

Answer 26

Wiskott Aldrich

Question 27

Adenosine deaminase deficiency (most common)

Answer 27

Severe combined immunodeficiency

Question 28

Deficiency in NADPH oxidase

Answer 28

Chronix granulomatous disease

Question 29

Absence of CD 18

Answer 29

Leukocyte adhesion defect

Question 30

Granule structural defect

Answer 30

Chediak Higashi syndrome

Question 31

Granule enzyme deficiency

Answer 31

Myeloperoxidase deficiency

Question 32

Deficiency in TNF gamma

Answer 32

Job’s syndrome

Question 33

Management for allergic rhintis

Answer 33

Avoidance of allergens, immunotherapy, topical budesonide, fluticasone, mometasone