Immunology and Allergology Flashcards
T-cells are detected in the thymus on what week of gestation
7th-8th
Mucosa associated lympoid tissues
Pe-L-T (Peyer’s patches, lymphoid follicles, tonsils, submucosal lymphoid tissue)
A protein released by Natural Killer Cells that creats pores on cell membranes of target cells resulting in lysis
Cytolysin
1st line of defense vs neonatal herpes infection
NKC
This Activates and influences production of eosinophils
IL-5
Largest immunoglobulin
IgM
Most abundant Ig, only Ig that can traverse the placenta
IgG
Ig predominantly found on the human B lymphocytes
IgD
Basis of tissue compatibilty in recipient donor screening
Human leukocyte antigens
Immunopathologic Rxn in: asthma, urticaria, allergic rhinitis, anaphylaxis
Type I ( immediate hypersensitivity)
Immunopathologic Rxn in: hemolytic disease, erythroblastosis fetalis, gradt rejection, chronic keratitis, goodpastures, blood transfusion, ITP
Type II (cytotoxic rxn)
Immunopathologic Rxn in: PSGN, serum sickness, RA, SLE, Steven Johnson syndrome, polyarteritis nodosa
Type III (Immune Complex Mediatied)
Immunopathologic Rxn in: PPD test, contact allergic dermatitis , syphilis. Leprosy
Type IV(Delayed type)
Bruton’s disease
X-linked agammaglobulinemia
Block in the development of preB to B cell due to a defect in heavy chain gene rearrangement
X-linked agammaglobinemia
Management for Burton’s disease
Gamma globulin IM once a month at interval of 2-3 weeks
Aberrant thymus or absence of(occuring at 12th week of gestation)
DiGeorge syndrome/ congenital thymic aplasia
Management for DiGeorge
Fetal thymus transplant
Other abnormalities associated with DiGeorge
Catch 22 ( cardiac abnorm, abnormal facies, thymic hypoplasia, cleft palate, hypocalcemia)
Selective defect in cell-mediated immunity with susceptibility to chronic candida infection of the skin and mucous membranes w/ or w/o endocrinopathy
Sever combined immunodeficiency disorder
Deficiency of tyrosine kinase that blocks B cell maturation
Bruton’s x-linked agammo
Deficiency of CD40L on activated T cell
X linked hyper IgM syndrome
Deficiency of IgA (most common)
Selective IgA deficiency
Delayed onset of maturation of normal IgG
Transient Agammaglobulinemia
Thymic hypoplasia
DiGeorge syndrome
Defect in cystoskeletal glycoprotein
Wiskott Aldrich
Adenosine deaminase deficiency (most common)
Severe combined immunodeficiency
Deficiency in NADPH oxidase
Chronix granulomatous disease
Absence of CD 18
Leukocyte adhesion defect
Granule structural defect
Chediak Higashi syndrome
Granule enzyme deficiency
Myeloperoxidase deficiency
Deficiency in TNF gamma
Job’s syndrome
Management for allergic rhintis
Avoidance of allergens, immunotherapy, topical budesonide, fluticasone, mometasone