Immunology Flashcards
What is the SLE auto antibody?
ANA
What is the leukocyte adhesion deficiency mechanism?
Deficiency in CD18 (B2 integrin)
Cell type involved in Type 4 hypersensitivity?
T cells
What is the effect of leukotriene on neutrophils?
Chemotaxis (attracts neutrophils to the site of infection)
What is the major positive acute phase protein in cats?
Serum amyloid A
What is the mutation responsible for leukocyte adhesion deficiency?
CD18+
CD markers of B lymphocyte?
CD21, CD45, CD79
Main cytokine secreted by natural killer cells?
IFN-gamma
Cytokines responsible for fever?
IL-1
IL-6
TNF-alpha
What does TLR4 recognize?
LPS in GM - bacteria
Name the mechanism of the four hypersensitivity reactions:
Type I: reaction mediated by IgE antibodies (immediate)
Type II: antibody-depended cell-mediated cytotoxicity
Type III: reaction mediated by immune complexes
Type IV: delayed reaction mediated by cellular response
Where are natural killer cells produced?
Bone marrow
What antibodies are present in systemic lupus?
ANA, CD4, T Cells, and B Cells
What is the Western Blot test used for?
Detects specific protein
What Th is associated with eosinophils?
Th2
What is the first step in the classical complement cascade?
C1 binds Ag-Ab
What cytokines are involved in fever?
IL-1, IL-6, TNF-a
What cell decreases with FIV/FeLV?
CD4+ (aka T Helper cells)
CD for B cells?
CD79a, CD21
What Ig is in upper resp tract?
IgA
In what cells does FIV virus replicate?
T cells
What cytokine is produced by NK cells?
IFN-γ
What is major histocompatibility complex (MHC) class II associated with?
CD4 lymphs [aka CD4 T cells (classical “helper” T cells)]
How do CD8+ lymphs kill cells?
Perforins
Which WBC is responsible for removing foreign material from the pulmonary alveoli?
Alveolar macrophages
What is the function of class II MHC molecules?
MHC II molecules are involved in the exogenous pathway and are expressed primarily on antigen-presenting cells; bind to peptides taken in from outside of the cell
ANY peptide in the endosome can be loaded on to class II. Self proteins from the extracellular fluid, proteins found in the cell membrane that are brought into the endosome, and pathogen-derived proteins.
