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Ophthalmology > Immunology > Flashcards

Immunology Flashcards

1
Q

Name some features of the innate immune system of the eye

A

Blink reflex
Lysozyme in tears
Immune cells (neutrophils/macrophages) in tears

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2
Q

What is the main antigen presenting cell for the eye?

A

Langerhans cells

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3
Q

Where are Langerhans cells most commonly found?

A

Limbus

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4
Q

What is the only part of the eye with lymphatic drainage?

A

Conjunctiva

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5
Q

What immune tissue is found in the conjunctiva?

A

Mucosa associated lymphoid tissue (MALT)

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6
Q

What is immune privilege?

A

The ability to tolerate the introduction of antigens without eliciting an inflammatory immune response

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7
Q

What is anterior chamber associated immune deviation?

A

The tolerance to a foreign antigen when placed in the ocular microenvironment

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8
Q

How is ocular immune privilege established?

A

No MHC molecules in cornea
No blood/lymphatic vessels in cornea
ACAID

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9
Q

What is sympathetic ophthalmia?

A

A bilateral granulomatous uveitis due to trauma in one eye

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10
Q

Does immune privilege play a role in sympathetic ophthalmia?

A

Yes

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11
Q

Which cell is thought to mediate sympathetic ophthalmia?

A

T cells

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12
Q

In sympathetic ophthalmia, the injured eye is the sympathising/exciting eye and the fellow eye is the sympathising/exciting eye

A

Exciting

Sympathising

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13
Q

Give examples of some ocular autoimmune diseases

A

Autoimmune uveoretinitis
Keratoconjunctivitis sicca
Sympathetic ophthalmia

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14
Q

Give an example of a type I hypersensitivity eye condition

A

Acute allergic conjunctivitis

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15
Q

In type II hypersensitivity, what are cells killed by?

A

Macrophages
NK cells
Complement

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16
Q

Give an example of a type II hypersensitivity eye condition

A

Ocular cicatricial pemphigoid

17
Q

Give an example of a type III hypersensitivity eye condition

A

Autoimmune corneal melting

18
Q

When can an eye exhibit type IV hypersensitivity?

A

Corneal graft rejection

19
Q

What aspects of immune privilege help in corneal transplants?

A

Reduced expression of MHC class I and II
Lack of blood and lymph vessels
Lack of Langerhans cells
ACAID

Ophthalmology (14 decks)

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