Immunology Flashcards
What physical barriers does the eye have?
Flushing
Mucous layer - antiadhesive
What chemical barriers does the eye have?
Lysozyme
Lactoferrin & transferrin
tear lipids
What does lysozyme defend against?
gram -ve
fungi
What does lactoferrin and transferrin defend against?
gram +ve
What cellular defence does the eye have?
Neutrophils - attracted by chemotaxis
Macrophages - phagocytosis of damaged cells
Conjunctival mast cells - vasoactive mediators
What 2 things does the acquired immune system need?
Antigen presenting cells
Lymphatic drainage to node
What is the only part of the eye with lymphatic drainage?
Conjuctiva
What act as the antigen presenting cells in the conjuctiva?
Dendritic cells
Do the cornea and sclera have lymphatic drainage?
No
What type of barrier does the vitreous, choroid and the retina have?
Blood-ocular
What is immune privilege?
Ability to tolerate antigens without eliciting an inflammatory response
What body parts have immune privilege?
Brain
Testes
Placenta/foetus
Eyes
What is Sympathetic Ophthalmia?
rare, bilateral, granulomatous uveitis due to trauma to one eye but causes blindness in both
Describe sympathetic ophthalmia?
Primary mediators are T cells
at start - CD4+ helper t cells
later - CD8+ cytotoxic T cells
What is type 1 hypersensitivity?
immeadiate hypersensitivity
