immunology Flashcards
HLA-A3
hemochromatosis
HLA-B27
seronegative arthropathies
HLA-DQ2/DQ8
celiac dz
HLA-DR2
MS, hay fever, SLE, goodpastures
HLA-DR3
T1DM, SLE, graves, hashimotos
HLA-DR4
RA, T1DM
HLA-DR5
pernicious anemia, hashimotos
type I HSR
IgE -> mast cell and basophil degranulation -> vasodilation of postcapillary venules -> delayed response from arachidonic acid metabolites (leukotrienes)
type II HSR
IgM, IgG bind to Ag on enemy cell -> cytotoxic killing via opsonization, complement + Fc receptor-mediated, and Ab-mediated cellular dysfxn. coombs test. acute transfusion rxns, AIHA, GBS, graves, MG, rheumatic fever, etc.
type III HSR
Ag, Ab, and complement get stuck together -> neutrophils release lysosomal enzymes. serum sickness and arthus rxn are specific types. SLE, post-strep glomerulonephritis, etc.
type IV HSR
NOT Ab-relatedd. delayed. T cells bind Ag -> cytokines -> macrophage activation. transplant rejection, TB skin test, touching (contact dermatitis). MS.
febrile nonhemolytic transfusion rxn
type II HSR. host Abs against donor HLA and WBCs -> fever, h/a, chills, flushing
acute hemolytic transfusion rxn
type II HSR. ABO incompatibility -> intravascular hemolysis, host Ab rxn w/foreign Ags -> extravascular hemolysis -> fever, hypotension, tachypnea, tachycardia, flank pain, hemoglobinuria (intravascular), jaundice (extravascular).
why does complement deficiency increase risk of SLE?
b/c complement is necessary to remove Ag/Ab complexes
anti-basement membrane
goodpastures
anticardiolipin, lupus anticoagulant
SLE, antiphospholipid
anticentromere
limited scleroderma (CREST)
anti-desmosome, anti-desmoglein
pemphigus vulgaris
anti-smith
SLE
anti-glutamic acid decarboxylase (GAD-65)
T1DM
antihemidesmosome
bullous pemphigoid
anti-histone
drug-induced lupus
anti-Jo-1, anti-SRP, anti-Mi-2
polymyositis, dermatomyositis
antimicrosomal, antithyroglobulin
hashimotos
antimitochondrial
PBS
antinuclear Abs
SLE, nonspecific
antiparietal cell
pernicious anemia
anti-Scl-70, anti-DNA topoisomerase I
scleroderma (diffuse)
anti-SSA, anti-SSB (anti-Ro, anti-La)
sjogrens
anti-smooth muscle
autoimmune hepatitis
anti-TSH
graves
anti-U1 RNP (ribonucleoprotein)
mixed connective tissue dz