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STEP1 > Immunology > Flashcards

Immunology Flashcards

1
Q

TH2

A

Antibody Mediated Immunity
Il-4
Il-5

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2
Q

TH1

A

Cell Mediated Immunity
Activated by IL-12
IL-2 - activates Cd8 T cells
Gamme Interferon - Activates Macrophages

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3
Q

IgM

A

Primary Response
Found on B-Cells
Does not Cross Placenta
Complement

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4
Q

CD 4 T Cells

A

Helper T Cells
Recognize MHC 11
4x2=8

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5
Q

CD8 T Cells

A

Cytotoxic T Cells
Recognize MHC 1
Usually intracellular pathogens (Virus)
8x1=8

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6
Q

Il-2

A

Stimulates T-cells (cd8)

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7
Q

Il-12

A

Stimulates Th1

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8
Q

interferon gamma

A

Stimulates Macrophages/NK cells

Increase MHC expression

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9
Q

Neutrophil Opsosinization

A

IL-8
C5a\
Leukotrien 4b

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10
Q

Il-10

A

Inhibitor of Inflammation

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11
Q

IgA

A

Mucous membrane
prevent bacterial attachment
no complement

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12
Q

iL-4

A

IgE and IgG class switch

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13
Q

IL-5

A

Class switching to IgA

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14
Q

Il-3

A

bone marrow stem cell growth

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15
Q

C3a, C4a, C5a

A

anaphylaxis

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16
Q

C3b

A

opsonization

17
Q

C5b-9

A

MAC complex

18
Q

Ataxia-telangiectasia

A

Defect in ATM gene - DNA repair

Ataxia, Angiomas, IgA deficiency

19
Q

Hyper IGM

A 
CD40L problem
cant class switch
20
Q

SCID

A

IL-2 receptor deficiency

Adenosine Deaminase Deficiency

21
Q

Transplant Rejection

A

Hyper Acute - Type 2
Acute - Type 2 and Type 4
Chronic -

22
Q

Graft vs Host

A

Graft T cell reacts against Host

23
Q

Granulatomiss Disease

A

NADH Oxidase Deficient

Prone to Catalase Bacteria

24
Q

Lymph Nodes

A

Follicle - B Cells
ParaCortex - T cells
Medulla - plasma cells

25
Q

T-Reg Cells

A

CD3

IL-10 and TGF-B

26
Q

IgG

A

Delayed Response
Cross Placenta
Complement

27
Q

IgE

A

Type 1 Hypersensitivy

Eosinophils - Worms

28
Q

Viral Vaccines

A

Live - Cellular Immunity

Killed - Humoral immunity

29
Q

C1 esterase inhibitor deficiency

A

Hereditary Angioedema

DONT USE ACE

30
Q

DAF (Gp1 anchored enzyme) deficiency

A

complement mediate rbc lysis

Paroxysmal nocturnal hemoglobinuria

31
Q

IL-6

A

Fever and stimulates production of acute phase proteins

32
Q

TNF-alpha

A

septic shock
activates endothelium
causes leukocyte recruitment
vascular leak

33
Q

Eosinophil Chemotaxis

A

Histamin

34
Q

Wiskott-Aldrich

A 
Was Gene - t cells can't recognize actin cytoskeleton
WATER
thrombocytopenic purpura
eczema
recurrent infections
35
Q

Chediak-higashi

A 
defect in lyososomal trfficiking (LYST)
phagosome-lyosome fusion
staph/strep infections
albinism
peripheral neuropathy
36
Q

You can Drink Beer at the Bar when your 21

A

CD-21
B-CELLS
RECEPTOR FOR eBv

37
Q

NK cells

A

cd16 and CD56

38
Q

Live Attenuated Vaccines

A 
MMR
polio(sabin)
influenza(intranasal)
varicella
yellow fever

STEP1 (21 decks)

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