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PPClues > Immunology > Flashcards

Immunology Flashcards

0
Q

Which cytokines do Th cells stimulate?

A

Everything other than IL-1

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1
Q

Which cytokine do Macrphages stimulate?

A

IL-1

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2
Q

Which enlarged lymph nodes are mos likely malignant?

A

Supraclavicular, epitrochlear (above elbow), inguinal.

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3
Q

What is CD8?

A

Tk(killer) or Ts(suppressor) cell; responds to MCH I (self).

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4
Q

Which of your cells express MCH I?

A

All except RBC’s or platelets.

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5
Q

What is CD4?

A

Th (helper) cell, responds to MCH II (nonself)

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6
Q

What type of immunity does Th1 provide?

A

Cell mediated

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7
Q

What type of immunity does Th2 provide?

A

Humoral

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8
Q

What do B cell deficiency patients die of?

A

Bacterial infection

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9
Q

What is common variableHypogammaglobulinemia?

A

Kids w/ B cells don’t differentiate into plasma cells. Low Ab.

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10
Q

What is Bruton’s Agammaglobulinemia?

A

Young adults with defective tyrosine kinase. No Ab. X linked.

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11
Q

What is job-buckley syndrome?

A

Redheaded females, stuck in IgE stage.

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12
Q

What is Multiple Myeloma?

A

Multiple osteolytic lesions, IgG, gamma light chains, rouleux.

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13
Q

What is Heavy chain disease?

A

IgA and Multiple Myeloma of the GI tract.

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14
Q

What is selective IgG2 deficiency?

A

Recurrent encapsulated infections

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15
Q

What is selective IgA deficiency?

A

Transfusion anaphylaxis, mucuous membrane infection.

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16
Q

What is hairy cell leukemia?

A

Fried egg/ sunburst appearance, TRAP +

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17
Q

What is ataxia talengiectasia?

A

Low IgA, neuro problems

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18
Q

What is Hyper IgM syndrome?

A

High IgM, low all other Abs

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19
Q

What do T cell deficiency pt. die of?

A

Viral infection

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20
Q

What is DiGoerge syndrome?

A

No thymus/inferior parathyroids, low Ca++

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21
Q

What is Chronic Mucocutaneous Candidiasis?

A

T cell defect against Candida albicans, chronic fatigue.

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22
Q

What is SCID?

A

No thymus, frayed long bones, baby dies by 18mo.

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23
Q

What is Wiscott-Aldriche?

A

Low IgM, low platelets, high IgA, eczema, petechiae.

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24
Q

What does the CD4 count tell you?

A

Status of HIV (normal=1,000).

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25
Q

What does the viral load tell you?

A

Progression of HIV.

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26
Q

What organs have the most CD4 receptors?

A

Blood vessels, brain, testicles, cervix, rectum.

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27
Q

What are the 3 tests used to screen for HIV?

A

ELISA: detects IgG Ab to p24 Ag
Western blot: see > 2 proteins
PCR: detects virus, used in babies

28
Q

What is the definition of AIDS?

A

CD<200?uL or clinical sx.

29
Q

What are the live vaccines?

A 
LiVe MMR BOYS
Varicella
Mumps
Mesles
Rubella
Rotavirus
BCG
Oral polio
Yellow fever
Smallpox
30
Q

What is primary biliary cirrhosis?

A

Anti mitochondrial Ab, pruritus, female

31
Q

What is primary sclerosing cholangitis?

A

p-ANCA, bile duct inflammation, onion skinning.

32
Q

What is Type I Autoimmune hepatitis?

A

Anti-SM Ab, young women

33
Q

What is Type II Autoimmune hepatitis?

A

Anti-LKM Ab, kids

34
Q

What is bullous pemphigoid?

A

Anti-hemidesmosome Ab, skin bullae

35
Q

What is celiac sprue?

A

Anti-gliadine Ab, eating wheat, steatorrhea

36
Q

What is CREST syndrome?

A

Anti-centrmere Ab

37
Q

What is dermatitis herpetiformis?

A

Anti-BMZ Ab, Anti-endomysial Ab, vesicles on anterior thigh

38
Q

What is dermatomyositis?

A

Anti-Jo-1 Ab, myositis + rash

39
Q

What is DM type 1?

A

Anti-islet cell, Anti-GAD Ab, polyuria, polydipsia, weight loss.

40
Q

What is drug induced lupus?

A

Anti-histone Ab, HIPPPE causes it

41
Q

What is gastritis type A?

A

Anti-parietal cell Ab, atrophic gastritis, adenoCA

42
Q

What is Goodpasture’s?

A

Anti-GBM Ab, attacks lung and kidney, RPGN

43
Q

What is Grave’s disease?

A

Anti-TSHr Ab, hyperthyroid, bug eyes, peritibial myxedema.

44
Q

What is Guillain-Berre?

A

Anti-ganglioside Ab, ascending paralysis, 2wks after URI

45
Q

What is Hashimoto’s?

A

Anti-microsomal Ab, TPO, hypothyroid

46
Q

What is ITP?

A

Anti-platelet Ab, Anti- GP2b/3a Ab, thrombocytopenia

47
Q

What is mixed CT disease?

A

Anti-RNP Ab.

48
Q

What is Mononucleosis?

A

Heterophile Ab, teenager w/ sore throat

49
Q

What is MPGN type II?

A

Anti- c3 convertase Ab, c3 nephritic factor

50
Q

What is multiple sclerosis?

A

Anti-myelin Ab, middle aged female w/ vision problems

51
Q

What is Myasthenia Gravis?

A

Anti-Achr Ab, female w/ ptosis, weaker as day goes by

52
Q

What is paroxysmal hemolysis?

A

Donath Landsteiner Ab, bleeds when cold

53
Q

What is pempigus vulgaris?

A

Anti-desmosome Ab, skin sloughs off when touched

54
Q

What is pernicious anemia?

A

Anti-IF Ab, Vit B12 def= Megaloblastic anemia

55
Q

What is polyartheritis nodosa?

A

p-ANCA Ab, attacks gut and kidney, HepB

56
Q

What is Post-Strep GN?

A

ASO Ab, nephritic w/ complement deposition

57
Q

What is rheumatoid arthritis?

A

Rheumatoid factor, pain worse in the morning

58
Q

What is Scleroderma?

A

Anti-Scl70= Anti-Topoisomerase, fibrosis, tight skin

59
Q

What is Sjogrens?

A

Anti-SSA Ab, dry “sand in eyes”, dry mouth, arthritis.

60
Q

What is SLE?

A

Anti-ds DNA/Sm/Cardiolipin, rash, photosensitivity, oral ulcers, RF.

61
Q

What is vitiligo?

A

Anti-melanocyte Ab, white patches

62
Q

What is SLE cerebritis?

A

Anti-neuronal Ab, Anti-ribosomal Ab.

63
Q

What is warm hemolysis?

A

Anti-Rh Ab, bleeds at body temperature

64
Q

What is Wegener’s?

A

c-ANCA Ab, attacks ENT, lung, kidney

65
Q

What is HSP?

A

IgA disease 2wks after common cold

66
Q

What is Berger’s?

A

IgA disease 2wks after vaccination= serum sickness

67
Q

What is Alport’s?

A

IgA disease 2wks after diarrhea.

PPClues (8 decks)

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