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Immunology Flashcards

0
Q

Which cytokines do Th cells stimulate?

A

Everything other than IL-1

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1
Q

Which cytokine do Macrphages stimulate?

A

IL-1

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2
Q

Which enlarged lymph nodes are mos likely malignant?

A

Supraclavicular, epitrochlear (above elbow), inguinal.

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3
Q

What is CD8?

A

Tk(killer) or Ts(suppressor) cell; responds to MCH I (self).

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4
Q

Which of your cells express MCH I?

A

All except RBC’s or platelets.

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5
Q

What is CD4?

A

Th (helper) cell, responds to MCH II (nonself)

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6
Q

What type of immunity does Th1 provide?

A

Cell mediated

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7
Q

What type of immunity does Th2 provide?

A

Humoral

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8
Q

What do B cell deficiency patients die of?

A

Bacterial infection

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9
Q

What is common variableHypogammaglobulinemia?

A

Kids w/ B cells don’t differentiate into plasma cells. Low Ab.

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10
Q

What is Bruton’s Agammaglobulinemia?

A

Young adults with defective tyrosine kinase. No Ab. X linked.

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11
Q

What is job-buckley syndrome?

A

Redheaded females, stuck in IgE stage.

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12
Q

What is Multiple Myeloma?

A

Multiple osteolytic lesions, IgG, gamma light chains, rouleux.

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13
Q

What is Heavy chain disease?

A

IgA and Multiple Myeloma of the GI tract.

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14
Q

What is selective IgG2 deficiency?

A

Recurrent encapsulated infections

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15
Q

What is selective IgA deficiency?

A

Transfusion anaphylaxis, mucuous membrane infection.

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16
Q

What is hairy cell leukemia?

A

Fried egg/ sunburst appearance, TRAP +

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17
Q

What is ataxia talengiectasia?

A

Low IgA, neuro problems

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18
Q

What is Hyper IgM syndrome?

A

High IgM, low all other Abs

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19
Q

What do T cell deficiency pt. die of?

A

Viral infection

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20
Q

What is DiGoerge syndrome?

A

No thymus/inferior parathyroids, low Ca++

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21
Q

What is Chronic Mucocutaneous Candidiasis?

A

T cell defect against Candida albicans, chronic fatigue.

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22
Q

What is SCID?

A

No thymus, frayed long bones, baby dies by 18mo.

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23
Q

What is Wiscott-Aldriche?

A

Low IgM, low platelets, high IgA, eczema, petechiae.

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24
What does the CD4 count tell you?
Status of HIV (normal=1,000).
25
What does the viral load tell you?
Progression of HIV.
26
What organs have the most CD4 receptors?
Blood vessels, brain, testicles, cervix, rectum.
27
What are the 3 tests used to screen for HIV?
ELISA: detects IgG Ab to p24 Ag Western blot: see > 2 proteins PCR: detects virus, used in babies
28
What is the definition of AIDS?
CD<200?uL or clinical sx.
29
What are the live vaccines?
``` LiVe MMR BOYS Varicella Mumps Mesles Rubella Rotavirus BCG Oral polio Yellow fever Smallpox ```
30
What is primary biliary cirrhosis?
Anti mitochondrial Ab, pruritus, female
31
What is primary sclerosing cholangitis?
p-ANCA, bile duct inflammation, onion skinning.
32
What is Type I Autoimmune hepatitis?
Anti-SM Ab, young women
33
What is Type II Autoimmune hepatitis?
Anti-LKM Ab, kids
34
What is bullous pemphigoid?
Anti-hemidesmosome Ab, skin bullae
35
What is celiac sprue?
Anti-gliadine Ab, eating wheat, steatorrhea
36
What is CREST syndrome?
Anti-centrmere Ab
37
What is dermatitis herpetiformis?
Anti-BMZ Ab, Anti-endomysial Ab, vesicles on anterior thigh
38
What is dermatomyositis?
Anti-Jo-1 Ab, myositis + rash
39
What is DM type 1?
Anti-islet cell, Anti-GAD Ab, polyuria, polydipsia, weight loss.
40
What is drug induced lupus?
Anti-histone Ab, HIPPPE causes it
41
What is gastritis type A?
Anti-parietal cell Ab, atrophic gastritis, adenoCA
42
What is Goodpasture's?
Anti-GBM Ab, attacks lung and kidney, RPGN
43
What is Grave's disease?
Anti-TSHr Ab, hyperthyroid, bug eyes, peritibial myxedema.
44
What is Guillain-Berre?
Anti-ganglioside Ab, ascending paralysis, 2wks after URI
45
What is Hashimoto's?
Anti-microsomal Ab, TPO, hypothyroid
46
What is ITP?
Anti-platelet Ab, Anti- GP2b/3a Ab, thrombocytopenia
47
What is mixed CT disease?
Anti-RNP Ab.
48
What is Mononucleosis?
Heterophile Ab, teenager w/ sore throat
49
What is MPGN type II?
Anti- c3 convertase Ab, c3 nephritic factor
50
What is multiple sclerosis?
Anti-myelin Ab, middle aged female w/ vision problems
51
What is Myasthenia Gravis?
Anti-Achr Ab, female w/ ptosis, weaker as day goes by
52
What is paroxysmal hemolysis?
Donath Landsteiner Ab, bleeds when cold
53
What is pempigus vulgaris?
Anti-desmosome Ab, skin sloughs off when touched
54
What is pernicious anemia?
Anti-IF Ab, Vit B12 def= Megaloblastic anemia
55
What is polyartheritis nodosa?
p-ANCA Ab, attacks gut and kidney, HepB
56
What is Post-Strep GN?
ASO Ab, nephritic w/ complement deposition
57
What is rheumatoid arthritis?
Rheumatoid factor, pain worse in the morning
58
What is Scleroderma?
Anti-Scl70= Anti-Topoisomerase, fibrosis, tight skin
59
What is Sjogrens?
Anti-SSA Ab, dry "sand in eyes", dry mouth, arthritis.
60
What is SLE?
Anti-ds DNA/Sm/Cardiolipin, rash, photosensitivity, oral ulcers, RF.
61
What is vitiligo?
Anti-melanocyte Ab, white patches
62
What is SLE cerebritis?
Anti-neuronal Ab, Anti-ribosomal Ab.
63
What is warm hemolysis?
Anti-Rh Ab, bleeds at body temperature
64
What is Wegener's?
c-ANCA Ab, attacks ENT, lung, kidney
65
What is HSP?
IgA disease 2wks after common cold
66
What is Berger's?
IgA disease 2wks after vaccination= serum sickness
67
What is Alport's?
IgA disease 2wks after diarrhea.

PPClues (8 decks)

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