Immunology Flashcards
which deficiency can cause recurrent chest infections
MBL deficiency
what deficiency can lead to more autoimmune conditiosn
C2 deficiency
What are the five types of primary immunodeficiencies
common variable immunodeficiency, hereditary angioedema, chronic granulomatous disease, x linked agammaglobulinaemia and severe combined immunodeficiency
on FBC: total b and t lymphocytes are low serum immunoglobulins are low
severe combined immunodeficiency
on FBC: total neutrophil count is low, neutrophil count is normal but on DHR there is a defect in oxidative burst step, serum immunoglobulins are riased
chronic granulomatous disease
patient has bradycardia, hypotension but no resp compromise what is it likely to be:
anaphylaxis
vasovagal syncope
panic attack
vasovagal syncope
patient has tachycardia, hypotension but abnormal o2 stats:
anaphylaxis
vasovagal syncope
panic attack
anaphylaxis
patient has tachycardia, hypotension but normal o2 stats:
anaphylaxis
vasovagal syncope
panic attack
panic attack
Function of IL4
mature b lymphocytes
Function of IL5
activate eosinophils
Dosage of adrenaline to give in anaphylaxis in adults
1:1000 0.5mg every 5 mins
Dosage of adrenaline to give in anaphylaxis in 4months
150ug in 6 months to 6 years
Dosage of adrenaline to give in anaphylaxis in 9 year old
300ug in 6-11 years
which type of arteritis presents with jaw claudication, headaches and uneven pulses
takayasu’s arteritis
Which type of vasculitidies is associated with renal artery stenosis
takayasu
ten warning signs of PID, need atleast two of these
1) Family history of PID
2) four or more ear infections in 1 year
3) two or more sinus infections in 1 year
4) two or more cases of pneumonia in 1 year
5) deep seated infections in three years
6) deep tissue abscesses
7) failure to grow as an infant
8) two or months of antibodies with little or no effect
9) use of IV antibiotics to clear infections
10) thrush in the mouth and other site within 6 months
low C4 normal C3 and normal c1eq inhibitor
type 2 HAE and nonfunction c1eq inhibitor
low C4, normal C3 and low c1eq inhibitor
type 1 HAE
what do basophils have in similar to mast cells
They release histamine and a IgE affinity receptors
What is a BAT test
This is basophil activation test- in vitro immunoassay that records basophil response to allergen through ?
Limitations of BAT
What is the ISAC and what can it detect
Which ethnicity is SLE more common in
africans, carribean and asians
What are the 5 antibodies found in SLE
thrombocytoenia, livedo reticularis and recurrent miscarriges
antiphospholipid syndrome
gold standard for allergy testing
when you do a blood culture in suspected pneumonia
if they have a fever
initial treatment for HAP
which of the following are genetic:
atopy, allergy, clinical allergy
a genetic tendency to produce antibodies to the environment, allergy: type i IgE mediated hypersenstivity reaction. clinical allergy: effects such as sneezing
what is associated with acrocyanosis
cold AIHA
what is intra and extravascular cold or warm AIHA
cold intravascular and warm is extravascular
donath-landsteiner antibody
cold paroxysmal haemoglobinuria
treatment for antiphospholipid syndrome
daily dose of aspirin
difference between ITP and TTP
ITP has petechiae without a fever and TTP also has AKI and confusion
