immunological investigation of multisystem A.I diseases Flashcards
1
Q
autoimmunity
A
predisposing factors
breakdown of immunological tolerance
pathological autorecognition
inflammation & tissue damage
2
Q
test purpose
A
disease -diagnosis - subclassification - prognosis -monitering treatment -planning -selection -triage - M&E
3
Q
immunology test
A
antinuclear antibodies antineutrophil cytoplasmic antibodies antiphospholipid antibodies complement cryoglobulins
4
Q
antibody production
A
Th2-> Bcell
5
Q
Antinuclear antibody
A
SLE (95%) drug induced Lupus Mixed connective tissue disorder RA sjogren scleroderma chronic inflammation old age neoplasia chronic active hepatitis
6
Q
ANA
A
high sensitivity low specificity SLE high negative value low positive predictive value ANA negative SLE unlikely
7
Q
types
A
homogeneous
speckled
nucleolar
peripheral
8
Q
homogeneous
A
dsDNA -SLE (60-90%) -some autoimmune liver disease ssDNA -non specific -many inflam disorders Histone proteins -drug induced lupus
9
Q
Speckled
A
Ro- Sjogren La- Sjogren Sm- SLE RNP- MCTD Scl-70- Scleroderma Jo-1- Polymyositis Centromere
10
Q
Nucleolar
A
nucleolus specific RNA
- Scleroderma, systemic sclerosis & ovrlap syndromes
- clinical variants
11
Q
peripheral
A
dsDNA
-SLE
12
Q
cascade testing
A
screening test-> specific test
13
Q
auto Ab
A
Anti- dsDNA= nephritis, vasculitis -Sm= nephritis, cerebral -RNP= Arthritis, myositis, Raynauds -Ro= photosensitivity, sjogren's cutaneous form of lupus
14
Q
Antinuclear cytoplasmic antibodies
A
small vessel vasculitis
1) ANCA-associated
2) immune complex associated
15
Q
ANCA
A
C-ANCA major autoantigen associated - proteinase 3 -> GPA P- ANCA Major autoantigen associated- Myeloperoxidase -> MPA ->EGPA (eosinophilic granulomatous polyangiitis)
