autoimmune and hyper sensitivity Flashcards
Connective tissue diseases
systemic lupus erythematosus
scleroderma
Sjogren’s syndrome
Systemic Vasculitis
Giant cell arteritis
granulomatosis polyangiitis
microscopic polyangiitis
A.I sequence of events
iniatiaing event genetic susceptibility breakdown of self tolerance autoreactivity humoral +/- celluar autoimmune disease
mimics
cocaine, HIV, endocarditis, lymphoma
SLE classification criteria
Malar rash discoid rash (alopecia=baldness) photosensitivity oral ulcers arthritis serosities (pleurisy or pericarditis) renal (casts or proteinuriaz) neurological haematological immunological ANA
scleroderma
limited -pulmonary hypertension Diffuse -pulmonary fibrosis -renal crisis- accelerated hypertension with microangiopathy leading to renal failure and death small bowel bacterial overgrowth
sjogren’s syndrome
dry eyes and mouth parotid gland enlargement 1/3 have systemic upset fatigue fever myalgia, arthralgia complication lymphoma, neuropathy purpura interstitial lung disease renal tubular acidosis
autoimmune myositis
muscle weakness- symmetrical, diffuse, proximal
MCTD mixed connective tissue disease
soft tissue swelling
raynauds
myositis
arthralgia
Large vessel vasculitis
takayasu arteritis
giant cell artertis
medium vessel vasculitis
polyarteritis nosa
kawasaki disease
small vessel vasculitis
microscopic polyangiitis granulomatous with polyangiitis eosinophilic granulomatosis immune complex SvV Anti GBM IgA vasculitis
Giant cell arteritis
poly myalgia like symtoms
blurred vision and visual loss
GCA
onset > 50 yrs
new headache-usually unilateral
temporal artery tenderness
ESR high
ANCA associated vasculitis
granulomatosis (wegener's) -involves upper and lower respi tract -necrotising granulomatous microscopic affecting small vessels pulmonary capillaritis eosiniphilic granulomatosis -associated with late onset asthma mononeuritis multiplex
