Immunoglobulin II Flashcards
Which Ig is best at complement fixation?
IgM
Which immunoglobulin is the only one that crosses the placental barrier?
IgG
Which Ig is best at mast cell degranulation?
IgE
Which Ig is best at Bacterial cell lysis?
IgM
Which Ig is the best at antiviral activity?
IgA
Which Ig(s) are best at toxin neutralization?
IgG and IgA
As a monomer, IgM serves as a….
Surface receptor on B cells for foreign antigens
What genes is the variable domain of the heavy chain broken into?
V, D, J
Which segment of the variable domain is the light chain missing?
D
What is the enzyme that does the recombination of antibodies and T cell receptors?
RAG-1 and RAG-2 recombinase
What syndrome results from the loss of RAG?
Omenn Syndrome
What is somatic mutation?
Variation of V, J, D and also the exonuclease and TDT variation
What is somatic hypermutation?
AID (activation induced deaminase), after somatic mutation happens, makes changes in cytosines to uracil.
Why is it that DV/DJ joints are “sloppy” and mutated?
The fragments are put together with the help of exonucleases, which chew away some nucleotides, but then they have nucleotides added by terminal deoxynucleotidyl transferase (TdT) which is entirely random
In a mu germline of B cells, what is the order by which chain domains are chosen?
Mu, Kappa, then if kappa doesn’t work, lambda
