Diebel Diseases

Question 0

This disease can occur when a proto-oncogene is placed next to the promoter of a T-cell receptor.

Answer 0

Acute lymphocytic leukemia

Question 1

This disease is characterized by a unique antibody arrangement that is extraordinarily prevalent in serum because of the proliferative nature of the cancerous parent cell

Answer 1

Burkitt’s lymphoma

Question 2

This disease is associated with a marked increase in progenitor cells to the lymphoid germline.

Answer 2

Acute myelogenous leukemia

Question 3

The lack of the normal distribution of lambda to kappa light chain domains can lead to the diagnosis of this malignancy.

Answer 3

Chronic lymphocytic leukemia

Question 4

This malignancy is due to the upregulation of a tyrosine kinase gene due to translocation. The IL-3 receptor is consistently turned on by the tyrosine kinase, leading to increased cellular proliferation

Answer 4

Chronic myelogenous leukemia

Question 5

This disorder is the result of an inherited defect in a tyrosine kinase, resulting in deficient immunoglobulin production by B cells. The disease may present as recurrent infections early on in life.

Answer 5

Bruton’s agammaglobulinemia (x-linked agammaglobulinemia)

Question 6

This disorder is seen when IgG levels fall to extremely low levels between the ages of 3-6 months. Causes are unknown.

Answer 6

Transient hypogammaglobulinemia of infancy

Question 7

This is a classification for general problems in antibody formation. It has been linked to a deficiency in the gene making NF-kB, but there are many causes for diseases under this classification.

Answer 7

Common variable immunodeficiency (defect in T cell signaling of B cell)

Question 8

This disorder is due to the inability of certain B cells to mature into plasma cells due to large deletions of the heavy chain loci in the genome

Answer 8

IgA and IgG subclass deficiencies

Question 9

The gene most likely associated with Burkitt’s lymphoma is…

Answer 9

c-myc