Immunizations/Infectious Diseases Flashcards
Vaccines stimulate
immune system to produce antigens
- same antigens as disease (killed or weakened)
What happens to the antibodies after destroying the antigens of the vaccine?
memory cells formed
Who decides what vaccines are needed?
CDC - pink book
American Academy of Pedi - red book
What are the best ways to prevent infectious diseases?
immunizations
handwashing
isolations (reduce cross-transmissions)
infection control
sneeze and cough etiquette
What is the best way to prevent complications of individuals at high risk? (steroids, immunodeficiency, hemolytic disease -sickle cell)
vaccinate
Why should a society vaccinate?
decrease/eliminate the infectious disease
Herd Immunity
85% majority with vaccine
If not enough people are vaccinated, what could potentially happen?
reemergence
example) measles, mumps, polio
Active Immunity
endogenous production of antibodies
long-lasting
months to develop
Natural Active Immunity
survive infection
Acquired Active Immunity
vaccination
Passive immunity
antibodies given to a person
immediate and short-lived
What is the most common passive immunity?
last 1-2 months of pregnancy mother passes gamma globulin to the baby and lasts up to a year
Antibody sources
blood products
immune globulins (diff. people in one)
hyperimmune globulins (specific antibody)
Antitoxins (horses)
What is a complication of antitoxin?
serum sickness from horses
Live Attenuated Vaccines
a weakened form of live
same as the infection itself
must replicate (can get the disease)
Live attenuated vaccines have how many doses?
1-2
Live attenuated vaccine effectiveness issues
circulating antibody (blood transfusion)
damage to organ (extreme temps and sunlight)
What vaccines are live attenuated?
MMR
Varicella
Rotavirus
Intranasal Influenza
How many doses do inactivated vaccines have to gain immunity?
2-3
Inactivated Vaccines are produced in
culture media
Inactivated Vaccines replication
cannot replicate ( does not cause disease)
Inactivated Vaccines is less affected by
circulating antibodies
Antibody titer
antibody levels in the blood
Which vaccine is most likely needed for a “booster”?
inactivated vaccine
Inactivated Vaccines types
Polio,
Hepatitis A and B
Rabies,
Influenza,
Acellular pertussis,
Human papillomavirus,
Diphtheria,
Tetanus,
Pneumococcal,
Meningococcal
Haemophilus influenzae type b (Hib)
BEFORE INTRODUCTION OF THE VACCINE
the leading cause of bacterial meningitis
invasive bacterial disease among children younger than 5 years
epiglottis
The Hib vaccine prevents against
epiglottitis
Haemophilus influenzae type b (Hib) has how many doses?
multiple no number
99% decrease with vaccine
Vaccine Factor for failure
Age/maternal antibody
Dose
Route
Storage and handling – lose potency or contaminated
Nutritional status – malnutrition low
Coexisting disease
Genetics
What is prepared for administering vaccines?
Immunization history every visit
Recommended schedule
Screening
Discuss benefits/risks - VIS
After-care instructions
Appropriate doses of ibuprofen and tylenol
National Childhood Vaccine Injury Act of 1986 (NCVIA)
includes
Injury compensation
adverse event reporting (DATE GIVEN and EDITION)
- any effect even if unsure it caused the event
VIS
Nursing Considerations for Vaccines
accurate user friendly
parent concern (empathy and participate with them)
avoid judgment
Give VIS before vaccination and answer questions
Tylenol and EMLA to minimize adverse effects
respect ultimate wishes
flexibility for different vaccines
Documentation for Vaccinations
Date
Manufacturer
Lot #
Who administered the vaccine with the address
VIS received date and edition
Route, Dose, Site
Informed Consent or Refusal
If vaccines are given too close together, what increases
adverse effects, spacing is important
Timing of antibody-containing blood products (Ig) should be scheduled appropriately for what vaccines?
live
Screening helps
identify contraindications and precautions
increases the risk of adverse effects
Live doses of vaccines should only be given after
1 year (MMR, Varicella)
Hib Vaccine
contraindications
severe allergic reaction after a previous dose or to a vaccine component
less than 6 weeks
Hib Vaccines allergic reaction to what
dry natural latex
Hib Vaccine
Precautions
moderate to severe acute illness with or without fever
MMR vaccine
contraindications
severe allergic reaction to the previous dose
severe immunodeficiency (chemo, sickle cell, HIV infection, immunocompromised)
pregnancy
MMR vaccine
precautions
recent (<11 months) receipt of antibody-containing blood product
moderate to severe acute illness with/without fever
Rotavirus
contraindications
severe allergic reaction after the previous dose
severe combined immunodeficiency
Hx of intussusception
Rotavirus
precautions
moderate to severe acute illness with or without fever
- chronic GI disease
Varicella
contraindications
Severe allergic reaction after previous doses
severe immunodeficiency and pregnancy
When a contraindication is present in vaccines, a vaccine should ________ administered
NOT be administered
When a vaccine precaution is present, vaccinations should generally be
deferred but if the risks outweigh the benefits
Varicella
precautions
recent (<11 months) receipt of antibody-containing blood product
moderate to severe acute illness with or without fever
Live attenuated Vaccine vs. inactivated Vaccine
Is it contraindicated, vaccinated, or precautioned for an Allergy to vaccine or component?
contraindicated; contraindicated
Live attenuated Vaccine vs. inactivated Vaccine
Is it contraindicated, vaccinated, or precautioned for an encephalopathy?
Not known in live; contraindicated in inactivated
Live attenuated Vaccine vs. inactivated Vaccine
Is it contraindicated, vaccinated, or precautioned for pregnancy?
Live= contraindicated
Inactived = Vaccinate (some exceptions)
Live attenuated Vaccine vs. inactivated Vaccine
Is it contraindicated, vaccinated, or precautioned for immunosuppression?
Live= contraindicated
Inactived = Vaccinate (some exceptions)
Live attenuated Vaccine vs. inactivated Vaccine
Is it contraindicated, vaccinated, or precautioned for moderate to severe illness?
precaution on both
Live attenuated Vaccine vs. inactivated Vaccine
Is it contraindicated, vaccinated, or precautioned for recent blood products?
Live: precaution till after 3-4 months
Inactivated = vaccinate
Invalid “contraindications” for vaccines
Mild illness
Antimicrobial/antibiotics therapy
Pregnant or immunosuppressed person in the household
Breastfeeding except small-pox
Preterm birth once to 2 kg
Allergy to products not in vaccine
Multiple vaccines
Local Adverse Events
Mild/self-limited
Pain/swelling/redness at the injection site
Within hours of injection
Local adverse reactions are common with
inactivated vaccines
Systemic reactions to vaccine
Fever/malaise/headache/myalgia/loss of appetite
Reactions following live vaccines may be similar to mild form of disease
Systemic reactions can occur how many days after administration
7-21
Which adverse reactions can be life-threatening?
allergic (anaphalaxis)
s/s and preparations are needed
How long should you observe the patient after vaccination for allergic reactions?
15 minutes
What s/s should be watched out for after vaccinations?
Respiratory distress, wheezing, shock like, hives, swelling in mouth and throat
What treatment is needed for allergic reactions?
IM Epipen
What vaccines are given SubQ?
MMR
Varicella
-live-
What vaccines could be IM or SubQ?
IPV (Inactivated Polio Vaccine)
PCV (Pneumococcal Vaccine)
MCV (Meningococcal Vaccine)
What vaccines are given IM?
DTaP/Tdap (Diphtheria, Tetanus, Acellular Pertussis)
Hepatitis A
Hepatitis B
Hib (Haemophilus Influenzae type B)
HPV (Human Papillomavirus)
Do you aspirate on a vaccine?
not required
- experience less pain when given rapidly without aspiration
Why are vaccines not given IVP?
veins and arteries are too small
If a child has a bleeding disorder, what could happen during the IM injection and how can it be prevented?
hematoma; 23 g or finer and firm pressure for 2 minutes (NO RUBBING)