Immunity to Infectious Disease Flashcards
What determines which immune tools are best suited for pathogen detection?
- entry site
- location
Mucosal pathogens
- effector subset
- cells
Th2 subset
- IL-4, IL-5, IL-13)
Cells
- NK
- soluble IgA
- mast cells with IgE
- MALT B and T cells
IL-13 induces…
- cellular repair/epithelial cell shedding and mucus
- contractility of mucosal smooth muscle
- activates macrophages
IL-5 function….
activates eosinophils to mediate ADCC
IL-5 function….
activates eosinophils to mediate ADCC
Extracellular pathogens
- effector subset
- cells
Th17 and Th2
Cells
- IgA, IgM, IgG
- phagocytic cells
- B cells
IL-17 produces….
- antimicrobial peptides for direct killing
- increases number of neutrophils
- recruits neutrophils
Intracellular pathogens (cytosolic and vesicular)
- effector subset
- cells
- response
Th1
- DTH response
Cells
- cytokines (IFN-g, IL-2, TNF-a)
- activated macrophages
- NK cells
-CTLs (FasL)
Response: activates macrophages, induces apoptosis
List the PRRs for viral innate immune responses.
- TLR
- ALR
RLR
What is an antiviral cytokine?
Type 1 IFN
How are viruses neutralized?
- antibodies
- NK cells (ADCC)
- phagocytosis
- IFN-g
- IL-2 activates CTLs
T/F. Antibodies eliminate extracellular and intracellular bacteria.
False. Intracellular bacteria are not effected by Ab
What is the cellular response to parasitic worms?
Th2 responses:
- IgE production and recruitment of eosinophils
- IL-4
- IL-5
- IL-13
- mast cell degranulation
- neutrophils
What PRRs are specific for fungal pathogens?
CLRs
- induce phagocytosis
Depletion of which T helper subset can lead to fungal infections?
Th1 and Th17
